Effect of dietary zearalenone on the performance, reproduction tract and serum biochemistry in young rats

Muzaffer Denli, Juan Carlos Blandon, Silvia Salado, Maria Elena Guynot, Jose Francisco Pérez

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Abstract

© 2016 The Author(s). The present study was conducted to determine the toxic dose response of a chronic dietary Zearalenone (ZEA) in weaned young rats. Sixty, 21-day-old, Sprague Dawley female rats were randomly allocated to five groups of four replicate cages containing three rats. Rats were fed diets with increasing amounts of ZEA (0, 0.5, 0.9, 1.8 and 3.6 mg/kg) for 4 weeks. Daily feed intake was reduced (P <.05) by feeding the ZEA diets with 0.9 and 3.6 mg ZEA/kg feed. Rats fed the diet containing 1.8 mg ZEA/kg increased (P <.05) the body weight gain (BWG) and reduced (P <.05) feed conversion rate (FCR) as compared to the control group. The two highest levels of dietary ZEA also increased (P <.05) the weight of the uterus. However, ovaries’ weight, timing of vaginal opening and the inter-oestrous interval were not affected by increasing the doses of dietary ZEA (P >.05). Similarly, serum concentrations of total protein, follicle-stimulating hormone and alanine aminotransferase, aspartate aminotransferase and alkaline phosphate activities were not altered by the ZEA treatments. In conclusion, our results indicated that a chronic dietary consumption of ZEA at concentrations of 1.8 mg ZEA/kg increases the BWG and the uterus weight of weaning female rats.
Original languageEnglish
Pages (from-to)619-622
JournalJournal of Applied Animal Research
Volume45
Issue number1
DOIs
Publication statusPublished - 2 Nov 2016

Keywords

  • Biochemistry
  • Ovaries
  • Uterus
  • Weaning rats
  • Zearalenone

Fingerprint

Dive into the research topics of 'Effect of dietary zearalenone on the performance, reproduction tract and serum biochemistry in young rats'. Together they form a unique fingerprint.

Cite this