Effect of cycloheximide on different stages of Drosophila melanogaster

R. Marcos, J. Lloberas, A. Creus, N. Xamena, O. Cabré

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10 Citations (Scopus)


Cycloheximide, an antibiotic inhibiting protein synthesis, exerted a toxic effect on different developmental stages egg, larva and adult of Drosophila melanogaster. At the egg stage the early embryos were most sensitive. With larvae, a strong decrease in viability was found, with no sex difference. In adults, there was a dose-effect relationship, mortality increasing with concentration. At 10 and 15 mM, males were more sensitive than females. There were consistent differences between the control and cycloheximide-fed females in respect of the average number of eggs deposited and offspring produced. © 1982.
Original languageEnglish
Pages (from-to)105-112
JournalToxicology Letters
Publication statusPublished - 1 Jan 1982


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