Effect of cycloheximide on different stages of Drosophila melanogaster

R. Marcos; J. Lloberas; A. Creus; N. Xamena; O. Cabré

doi:https://doi.org/10.1016/0378-4274(82)90145-X

Effect of cycloheximide on different stages of Drosophila melanogaster

R. Marcos, J. Lloberas, A. Creus, N. Xamena, O. Cabré

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Abstract

Cycloheximide, an antibiotic inhibiting protein synthesis, exerted a toxic effect on different developmental stages egg, larva and adult of Drosophila melanogaster. At the egg stage the early embryos were most sensitive. With larvae, a strong decrease in viability was found, with no sex difference. In adults, there was a dose-effect relationship, mortality increasing with concentration. At 10 and 15 mM, males were more sensitive than females. There were consistent differences between the control and cycloheximide-fed females in respect of the average number of eggs deposited and offspring produced. © 1982.

Original language	English
Pages (from-to)	105-112
Journal	Toxicology Letters
Volume	13
DOIs	https://doi.org/10.1016/0378-4274(82)90145-X
Publication status	Published - 1 Jan 1982

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title = "Effect of cycloheximide on different stages of Drosophila melanogaster",

abstract = "Cycloheximide, an antibiotic inhibiting protein synthesis, exerted a toxic effect on different developmental stages egg, larva and adult of Drosophila melanogaster. At the egg stage the early embryos were most sensitive. With larvae, a strong decrease in viability was found, with no sex difference. In adults, there was a dose-effect relationship, mortality increasing with concentration. At 10 and 15 mM, males were more sensitive than females. There were consistent differences between the control and cycloheximide-fed females in respect of the average number of eggs deposited and offspring produced. {\textcopyright} 1982.",

author = "R. Marcos and J. Lloberas and A. Creus and N. Xamena and O. Cabr{\'e}",

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T1 - Effect of cycloheximide on different stages of Drosophila melanogaster

AU - Marcos, R.

AU - Lloberas, J.

AU - Creus, A.

AU - Xamena, N.

AU - Cabré, O.

PY - 1982/1/1

Y1 - 1982/1/1

N2 - Cycloheximide, an antibiotic inhibiting protein synthesis, exerted a toxic effect on different developmental stages egg, larva and adult of Drosophila melanogaster. At the egg stage the early embryos were most sensitive. With larvae, a strong decrease in viability was found, with no sex difference. In adults, there was a dose-effect relationship, mortality increasing with concentration. At 10 and 15 mM, males were more sensitive than females. There were consistent differences between the control and cycloheximide-fed females in respect of the average number of eggs deposited and offspring produced. © 1982.

AB - Cycloheximide, an antibiotic inhibiting protein synthesis, exerted a toxic effect on different developmental stages egg, larva and adult of Drosophila melanogaster. At the egg stage the early embryos were most sensitive. With larvae, a strong decrease in viability was found, with no sex difference. In adults, there was a dose-effect relationship, mortality increasing with concentration. At 10 and 15 mM, males were more sensitive than females. There were consistent differences between the control and cycloheximide-fed females in respect of the average number of eggs deposited and offspring produced. © 1982.

U2 - https://doi.org/10.1016/0378-4274(82)90145-X

DO - https://doi.org/10.1016/0378-4274(82)90145-X

M3 - Article

SN - 0378-4274

VL - 13

SP - 105

EP - 112

JO - Toxicology Letters

JF - Toxicology Letters

ER -

Effect of cycloheximide on different stages of Drosophila melanogaster

Abstract

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