Eleven prepubertal children with short stature were treated with clonidine (0.15 mg/m2 daily) for a period of 1 year. The effect of this drug was evaluated on both clinical (growth velocity, height standard deviation scores for chronological age and bone age) and hormonal (urinary growth hormone excretion and insulin-like growth factor I) parameters. Our study shows that long-term clonidine administration in children with shon stature did not result in significant differences in growth velocity, height standard deviation scores for chronological age and bone age, insulin-like growth factor I or in urinary growth hormone excretion. © 1990 S. Karger AG, Basel.
- Short stature
- Urinary growth hormone excretion
Sanmarti, A., Lucas, A., Granada, M. L., Salinas, I., Reverter, J. L., Cuatrecasas, J. M., Foz, M., & Audi, L. (1990). Effect of chronic clonidine treatment on urinary growth hormone excretion and linear growth in children with short stature. Hormone Research in Paediatrics, 34(5-6), 193-196. https://doi.org/10.1159/000181824