Effect of Androgens on Antipyrine Metabolism in the Rabbit

P. Salvá, J. Laporte, E. Saura, J. A. Salvá

    Research output: Contribution to journalArticleResearchpeer-review


    The inactivation of endogenous steroids and foreign compounds by the liver hydroxylative pathway, can be modified by androgenic substances. The inhibitory or inductory activity, can be estimated by measuring the half‐life of antipyrine. Androgens (testosterone propionate, 5α‐dihydro‐testosterone and mesterolone) reduce antipyrine metabolism in male rabbits. In females, androgens are not inhibitors, but one of them, 5α‐dihydrotestosterone, shows an inductive effect on liver oxidative mechanisms. Copyright © 1978, Wiley Blackwell. All rights reserved
    Original languageEnglish
    Pages (from-to)141-144
    JournalInternational Journal of Andrology
    Issue number1-6
    Publication statusPublished - 1 Jan 1978


    • 5α‐dihydrotestosterone
    • androgens
    • antipyrine half‐life
    • drug‐metabolism
    • mesterolone
    • testosterone propionate


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