Effect of Androgens on Antipyrine Metabolism in the Rabbit

P. Salvá; J. Laporte; E. Saura; J. A. Salvá

doi:10.1111/j.1365-2605.1978.tb00586.x

Effect of Androgens on Antipyrine Metabolism in the Rabbit

P. Salvá, J. Laporte, E. Saura, J. A. Salvá

Research output: Contribution to journal › Article › Research › peer-review

Abstract

The inactivation of endogenous steroids and foreign compounds by the liver hydroxylative pathway, can be modified by androgenic substances. The inhibitory or inductory activity, can be estimated by measuring the half‐life of antipyrine. Androgens (testosterone propionate, 5α‐dihydro‐testosterone and mesterolone) reduce antipyrine metabolism in male rabbits. In females, androgens are not inhibitors, but one of them, 5α‐dihydrotestosterone, shows an inductive effect on liver oxidative mechanisms. Copyright © 1978, Wiley Blackwell. All rights reserved

Original language	English
Pages (from-to)	141-144
Journal	International Journal of Andrology
Volume	1
Issue number	1-6
DOIs	https://doi.org/10.1111/j.1365-2605.1978.tb00586.x
Publication status	Published - 1 Jan 1978

Keywords

5α‐dihydrotestosterone
androgens
antipyrine half‐life
drug‐metabolism
mesterolone
testosterone propionate

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10.1111/j.1365-2605.1978.tb00586.x

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title = "Effect of Androgens on Antipyrine Metabolism in the Rabbit",

abstract = "The inactivation of endogenous steroids and foreign compounds by the liver hydroxylative pathway, can be modified by androgenic substances. The inhibitory or inductory activity, can be estimated by measuring the half‐life of antipyrine. Androgens (testosterone propionate, 5α‐dihydro‐testosterone and mesterolone) reduce antipyrine metabolism in male rabbits. In females, androgens are not inhibitors, but one of them, 5α‐dihydrotestosterone, shows an inductive effect on liver oxidative mechanisms. Copyright {\textcopyright} 1978, Wiley Blackwell. All rights reserved",

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year = "1978",

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doi = "10.1111/j.1365-2605.1978.tb00586.x",

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AU - Salvá, P.

AU - Laporte, J.

AU - Saura, E.

AU - Salvá, J. A.

PY - 1978/1/1

Y1 - 1978/1/1

N2 - The inactivation of endogenous steroids and foreign compounds by the liver hydroxylative pathway, can be modified by androgenic substances. The inhibitory or inductory activity, can be estimated by measuring the half‐life of antipyrine. Androgens (testosterone propionate, 5α‐dihydro‐testosterone and mesterolone) reduce antipyrine metabolism in male rabbits. In females, androgens are not inhibitors, but one of them, 5α‐dihydrotestosterone, shows an inductive effect on liver oxidative mechanisms. Copyright © 1978, Wiley Blackwell. All rights reserved

AB - The inactivation of endogenous steroids and foreign compounds by the liver hydroxylative pathway, can be modified by androgenic substances. The inhibitory or inductory activity, can be estimated by measuring the half‐life of antipyrine. Androgens (testosterone propionate, 5α‐dihydro‐testosterone and mesterolone) reduce antipyrine metabolism in male rabbits. In females, androgens are not inhibitors, but one of them, 5α‐dihydrotestosterone, shows an inductive effect on liver oxidative mechanisms. Copyright © 1978, Wiley Blackwell. All rights reserved

KW - 5α‐dihydrotestosterone

KW - androgens

KW - antipyrine half‐life

KW - drug‐metabolism

KW - mesterolone

KW - testosterone propionate

U2 - 10.1111/j.1365-2605.1978.tb00586.x

DO - 10.1111/j.1365-2605.1978.tb00586.x

M3 - Article

VL - 1

SP - 141

EP - 144

IS - 1-6

ER -

Effect of Androgens on Antipyrine Metabolism in the Rabbit

Abstract

Keywords

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