Effect of Androgens on Antipyrine Metabolism in the Rabbit

P. Salvá, J. Laporte, E. Saura, J. A. Salvá

    Research output: Contribution to journalArticleResearchpeer-review

    Abstract

    The inactivation of endogenous steroids and foreign compounds by the liver hydroxylative pathway, can be modified by androgenic substances. The inhibitory or inductory activity, can be estimated by measuring the half‐life of antipyrine. Androgens (testosterone propionate, 5α‐dihydro‐testosterone and mesterolone) reduce antipyrine metabolism in male rabbits. In females, androgens are not inhibitors, but one of them, 5α‐dihydrotestosterone, shows an inductive effect on liver oxidative mechanisms. Copyright © 1978, Wiley Blackwell. All rights reserved
    Original languageEnglish
    Pages (from-to)141-144
    JournalInternational Journal of Andrology
    Volume1
    Issue number1-6
    DOIs
    Publication statusPublished - 1 Jan 1978

    Keywords

    • 5α‐dihydrotestosterone
    • androgens
    • antipyrine half‐life
    • drug‐metabolism
    • mesterolone
    • testosterone propionate

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  • Cite this

    Salvá, P., Laporte, J., Saura, E., & Salvá, J. A. (1978). Effect of Androgens on Antipyrine Metabolism in the Rabbit. International Journal of Andrology, 1(1-6), 141-144. https://doi.org/10.1111/j.1365-2605.1978.tb00586.x