Effect of age and gender in the pharmacokinetics of albendazole and albendazole sulphoxide enantiomers in goats

B. P.S. Capece, S. M.S. Afonso, R. Lazáro, M. Harun, C. Godoy, G. Castells, C. Cristòfol

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10 Citations (Scopus)

Abstract

The kinetics of albendazole metabolites and albendazole sulphoxide enantiomers were studied in 2- and 14-month-old female and male goats, after a single oral dose administration (10 mg/kg) of an albendazole formulation. Blood samples from the jugular vein were collected at 0.5, 1, 2, 4, 6, 8, 10, 12, 16, 20, 24, 30, 36, 42, 48 and 54 h post-treatment and analyzed using a high performance liquid chromatography method. In all groups the area under the plasma concentration-time curve (AUC) and peak concentration (Cmax) values of (+)-ABZSO were significantly higher than those of (-)-ABZSO. The AUC and Cmax values obtained for (+)-ABZSO and (-)-ABZSO in adult animals were higher compared to the results in young animals, showing significant differences except for (+)-ABZSO in female animals. In young animals, independently of gender, the Cmax appeared earlier compared to adult animals. The mean residence time (MRT) values were shorter in young animals compared to adult animals for all compounds analyzed. No sex-related differences were found for any of the parameters calculated except for the (+)-ABZSO from adult animals. © 2008 Elsevier Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)498-502
JournalResearch in Veterinary Science
Volume86
DOIs
Publication statusPublished - 1 Jun 2009

Keywords

  • Age
  • Albendazole
  • Albendazole sulphoxide
  • Enantiomers
  • Gender
  • Goats
  • Pharmacokinetics

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