Abstract
© 2014, ESMRMB. Objective: We sought to evaluate the effects of acute hyperglycemia induced by intraperitoneal injection of glucose (2.7 g/kg) on vascular delivery to GL261 mouse gliomas kept at moderate hypothermia (~30 °C).Materials and methods: Seven GL261 glioma-bearing mice were studied by T1-weighted DCE MRI before and after an injection of glucose (n = 4) or saline (n = 3). Maximum relative contrast enhancement (RCE) and initial area under the enhancement curve (IAUC) were determined in each pixel.Results: The mean tumor parameter values showed no significant changes after injecting either saline (RCE −5.9 ± 5.0 %; IAUC −3.7 ± 3.6 %) or glucose (RCE −1.6 ± 9.0 %; IAUC +0.6 ± 6.4 %). Pixel-by-pixel analysis revealed small post-injection changes in RCE and IAUC between the glucose and saline groups, all within 13 % range of their baseline values.Conclusion: Perturbing the metabolism of GL261 tumors kept at moderate hypothermia with hyperglycemia did not induce significant changes in the permeability/perfusion of these tumors. This is relevant for future studies with this model since regional differences in glucose accumulation could thus reflect basal heterogeneities in vasculature and/or metabolism of GL261 tumors.
Original language | English |
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Pages (from-to) | 119-126 |
Journal | Magnetic Resonance Materials in Physics, Biology and Medicine |
Volume | 28 |
Issue number | 2 |
DOIs | |
Publication status | Published - 1 Apr 2015 |
Keywords
- Acute hyperglycemia
- Brain tumor
- Contrast agent
- GL261 cells
- Model-free quantification
- Moderate hypothermia
- Perfusion
- Permeability