Effect of 6β-methylprednisolone on mouse pregnancy rate

Esther Velilla; Mark Grossmann; Josep Egozcue; Josep Santaló

doi:10.1093/humrep/14.1.207

Effect of 6β-methylprednisolone on mouse pregnancy rate

Esther Velilla, Mark Grossmann, Josep Egozcue, Josep Santaló

Department of Cellular Biology, Physiology and Immunology

Research output: Contribution to journal › Article › Research › peer-review

1 Citation (Scopus)

Abstract

The aim of this study was to evaluate the effect of methylprednisolone on the pregnancy rate in mice. For this reason, zona pellucida-intact and zona pellucida-free embryos at the blastocyst stage were transferred to recipient mice at day 2.5 of pseudopregnancy. Embryo transfer was performed into non-immunodepressed and immunodepressed groups of recipient mice using 0.3 or 0.6 μg/g of 6β-methylprednisolone. A higher implantation and developmental rate of zona-free embryos transferred to the immunodepressed group of recipients was observed after using the higher dose of methylprednisolone.

Original language	English
Pages (from-to)	207-210
Journal	Human Reproduction
Volume	14
Issue number	1
DOIs	https://doi.org/10.1093/humrep/14.1.207
Publication status	Published - 1 Jan 1999

Keywords

Developmental rate
Embryo transfer
Immunodepression
Implantation rate
Methylprednisolone

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title = "Effect of 6β-methylprednisolone on mouse pregnancy rate",

abstract = "The aim of this study was to evaluate the effect of methylprednisolone on the pregnancy rate in mice. For this reason, zona pellucida-intact and zona pellucida-free embryos at the blastocyst stage were transferred to recipient mice at day 2.5 of pseudopregnancy. Embryo transfer was performed into non-immunodepressed and immunodepressed groups of recipient mice using 0.3 or 0.6 μg/g of 6β-methylprednisolone. A higher implantation and developmental rate of zona-free embryos transferred to the immunodepressed group of recipients was observed after using the higher dose of methylprednisolone.",

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author = "Esther Velilla and Mark Grossmann and Josep Egozcue and Josep Santal{\'o}",

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AU - Grossmann, Mark

AU - Egozcue, Josep

AU - Santaló, Josep

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AB - The aim of this study was to evaluate the effect of methylprednisolone on the pregnancy rate in mice. For this reason, zona pellucida-intact and zona pellucida-free embryos at the blastocyst stage were transferred to recipient mice at day 2.5 of pseudopregnancy. Embryo transfer was performed into non-immunodepressed and immunodepressed groups of recipient mice using 0.3 or 0.6 μg/g of 6β-methylprednisolone. A higher implantation and developmental rate of zona-free embryos transferred to the immunodepressed group of recipients was observed after using the higher dose of methylprednisolone.

KW - Developmental rate

KW - Embryo transfer

KW - Immunodepression

KW - Implantation rate

KW - Methylprednisolone

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DO - 10.1093/humrep/14.1.207

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