Early clinical impact of iron overload in stem cell transplantation. A prospective study

Albert Altes, Angel Francisco Remacha, Pilar Sarda, Montserrat Baiget, Anna Sureda, Rodrigo Martino, Javier Briones, Salut Brunet, Carme Canals, Jorge Sierra

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56 Citations (Scopus)


Toxic-infectious complications may be related with iron toxicity after a stem cell transplant (SCT). Eighty one patients who underwent SCT were prospectively evaluated over 3 months for mucositis, bacteraemia and febrile days. Pre-SCT transferrin saturation (TS), ferritin level and the number of days with TS≤80% after transplant were determined. A ferritin level >1,500 μg/l predicted the appearance of severe mucositis, bacteraemia and days with fever in univariate (P=0.03, P=0.03 and P=0.03) and multivariate analysis (P=0.03, P=0.006 and P=0.002). Nevertheless, further statistical studies revealed that the predictive value of pre-SCT ferritin levels was restricted to AUTO-transplanted patients in both univariate (P=0.05, P=0.05 and P<0.001) and multivariate (P=0.03, P=0.05 and P<0.001) analysis, in contrast with the ALLO-transplanted group where this variable did not reach statistical significance. In conclusion, iron burden seems to influence the appearance of toxic-infectious complications during the first 3 months after transplant in AUTO-transplanted patients. © Springer-Verlag 2007.
Original languageEnglish
Pages (from-to)443-447
JournalAnnals of Hematology
Publication statusPublished - 1 Jun 2007


  • Bacteraemia
  • Febrile days
  • Iron overload
  • Mucositis
  • Stem cell transplantation


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