TY - JOUR
T1 - Early clinical impact of iron overload in stem cell transplantation. A prospective study
AU - Altes, Albert
AU - Remacha, Angel Francisco
AU - Sarda, Pilar
AU - Baiget, Montserrat
AU - Sureda, Anna
AU - Martino, Rodrigo
AU - Briones, Javier
AU - Brunet, Salut
AU - Canals, Carme
AU - Sierra, Jorge
PY - 2007/6/1
Y1 - 2007/6/1
N2 - Toxic-infectious complications may be related with iron toxicity after a stem cell transplant (SCT). Eighty one patients who underwent SCT were prospectively evaluated over 3 months for mucositis, bacteraemia and febrile days. Pre-SCT transferrin saturation (TS), ferritin level and the number of days with TS≤80% after transplant were determined. A ferritin level >1,500 μg/l predicted the appearance of severe mucositis, bacteraemia and days with fever in univariate (P=0.03, P=0.03 and P=0.03) and multivariate analysis (P=0.03, P=0.006 and P=0.002). Nevertheless, further statistical studies revealed that the predictive value of pre-SCT ferritin levels was restricted to AUTO-transplanted patients in both univariate (P=0.05, P=0.05 and P<0.001) and multivariate (P=0.03, P=0.05 and P<0.001) analysis, in contrast with the ALLO-transplanted group where this variable did not reach statistical significance. In conclusion, iron burden seems to influence the appearance of toxic-infectious complications during the first 3 months after transplant in AUTO-transplanted patients. © Springer-Verlag 2007.
AB - Toxic-infectious complications may be related with iron toxicity after a stem cell transplant (SCT). Eighty one patients who underwent SCT were prospectively evaluated over 3 months for mucositis, bacteraemia and febrile days. Pre-SCT transferrin saturation (TS), ferritin level and the number of days with TS≤80% after transplant were determined. A ferritin level >1,500 μg/l predicted the appearance of severe mucositis, bacteraemia and days with fever in univariate (P=0.03, P=0.03 and P=0.03) and multivariate analysis (P=0.03, P=0.006 and P=0.002). Nevertheless, further statistical studies revealed that the predictive value of pre-SCT ferritin levels was restricted to AUTO-transplanted patients in both univariate (P=0.05, P=0.05 and P<0.001) and multivariate (P=0.03, P=0.05 and P<0.001) analysis, in contrast with the ALLO-transplanted group where this variable did not reach statistical significance. In conclusion, iron burden seems to influence the appearance of toxic-infectious complications during the first 3 months after transplant in AUTO-transplanted patients. © Springer-Verlag 2007.
KW - Bacteraemia
KW - Febrile days
KW - Iron overload
KW - Mucositis
KW - Stem cell transplantation
U2 - https://doi.org/10.1007/s00277-007-0266-x
DO - https://doi.org/10.1007/s00277-007-0266-x
M3 - Article
VL - 86
SP - 443
EP - 447
ER -