TY - JOUR
T1 - Dynamism, sensitivity, and consequences of mesenchymal and stem-like phenotype of cancer cells
AU - Gener, Petra
AU - Seras-Franzoso, Joaquin
AU - Callejo, Patricia González
AU - Andrade, Fernanda
AU - Rafael, Diana
AU - Martínez, Francesc
AU - Montero, Sara
AU - Arango, Diego
AU - Sayós, Joan
AU - Abasolo, Ibane
AU - Schwartz, Simó
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Copyright © 2018 Petra Gener et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. There are remarkable similarities in the description of cancer stem cells (CSCs) and cancer cells with mesenchymal phenotype. Both cell types are highly tumorigenic, resistant against common anticancer treatment, and thought to cause metastatic growth. Moreover, cancer cells are able to switch between CSC and non-CSC phenotypes and vice versa, to ensure the necessary balance within the tumor. Likewise, cancer cells can switch between epithelial and mesenchymal phenotypes via well-described transition (EMT/MET) that is thought to be crucial for tumor propagation. In this review, we discuss whether, and to which extend, the CSCs and mesenchymal cancer cells are overlapping phenomena in terms of mechanisms, origin, and implication for cancer treatment. As well, we describe the dynamism of both phenotypes and involvement of the tumor microenvironment in CSC reversion and in EMT.
AB - Copyright © 2018 Petra Gener et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. There are remarkable similarities in the description of cancer stem cells (CSCs) and cancer cells with mesenchymal phenotype. Both cell types are highly tumorigenic, resistant against common anticancer treatment, and thought to cause metastatic growth. Moreover, cancer cells are able to switch between CSC and non-CSC phenotypes and vice versa, to ensure the necessary balance within the tumor. Likewise, cancer cells can switch between epithelial and mesenchymal phenotypes via well-described transition (EMT/MET) that is thought to be crucial for tumor propagation. In this review, we discuss whether, and to which extend, the CSCs and mesenchymal cancer cells are overlapping phenomena in terms of mechanisms, origin, and implication for cancer treatment. As well, we describe the dynamism of both phenotypes and involvement of the tumor microenvironment in CSC reversion and in EMT.
U2 - 10.1155/2018/4516454
DO - 10.1155/2018/4516454
M3 - Review article
C2 - 30405720
SN - 1687-9678
VL - 2018
JO - Stem Cells International
JF - Stem Cells International
M1 - 4516454
ER -
