Dynamism, sensitivity, and consequences of mesenchymal and stem-like phenotype of cancer cells

Petra Gener, Joaquin Seras-Franzoso, Patricia González Callejo, Fernanda Andrade, Diana Rafael, Francesc Martínez, Sara Montero, Diego Arango, Joan Sayós, Ibane Abasolo, Simó Schwartz

    Research output: Contribution to journalReview articleResearchpeer-review

    7 Citations (Scopus)

    Abstract

    Copyright © 2018 Petra Gener et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. There are remarkable similarities in the description of cancer stem cells (CSCs) and cancer cells with mesenchymal phenotype. Both cell types are highly tumorigenic, resistant against common anticancer treatment, and thought to cause metastatic growth. Moreover, cancer cells are able to switch between CSC and non-CSC phenotypes and vice versa, to ensure the necessary balance within the tumor. Likewise, cancer cells can switch between epithelial and mesenchymal phenotypes via well-described transition (EMT/MET) that is thought to be crucial for tumor propagation. In this review, we discuss whether, and to which extend, the CSCs and mesenchymal cancer cells are overlapping phenomena in terms of mechanisms, origin, and implication for cancer treatment. As well, we describe the dynamism of both phenotypes and involvement of the tumor microenvironment in CSC reversion and in EMT.
    Original languageEnglish
    Article number4516454
    JournalStem Cells International
    Volume2018
    DOIs
    Publication statusPublished - 1 Jan 2018

    Fingerprint

    Dive into the research topics of 'Dynamism, sensitivity, and consequences of mesenchymal and stem-like phenotype of cancer cells'. Together they form a unique fingerprint.

    Cite this