TY - JOUR
T1 - Dynamics of porcine circovirus type 2 infection in a herd of pigs with postweaning multisystemic wasting syndrome
AU - Rodríguez-Arrioja, Gabriela M.
AU - Segalés, Joaquim
AU - Calsamiglia, Maria
AU - Resendes, Ana R.
AU - Balasch, Mònica
AU - Plana-Durán, Juan
AU - Casal, Jordi
AU - Domingo, Mariano
PY - 2002/3/1
Y1 - 2002/3/1
N2 - Objective-To determine the pattern of infection for porcine circovirus type 2 (PCV2) in a herd of pigs with postweaning multisystemic wasting syndrome (PMWS). Animals-29 sows and 250 pigs. Procedure-Blood samples were collected from all 3-, 7-, and 12-week old pigs and 59 pigs at 28 weeks of age. Pigs that died during the study were necropsied. Porcine parvovirus and PCV2 antibodies were assayed. A polymerase chain reaction (PCR) was used to detect PCV2 genome in serum of selected pigs. Results-The PMWS started when pigs were 8 weeks old, with a prevalence of 30% in 8- to 10-week-old pigs. Eighty-three pigs died during the period between 3 and 12 weeks of age. Microscopic lesions consistent with PMWS were observed, and PCV2 nucleic acid was detected (50 of 68 pigs). Antibodies to PCV2 decreased from 3 to 7 weeks of age, increased at 12 weeks of age, and were maintained until 28 weeks of age. One sow had a positive result for PCR of serum. Nine, 37, and 8 pigs had PCV2 genome in serum obtained at 7, 12, and 28 weeks of age, respectively. Conclusions and Clinical Relevance-Infection with PCV2 coincided with severe clinical signs; however, infected 28-week-old pigs did not have evidence of disease. Immunity declined over time in young pigs. A long duration of PCV2 viremia was apparent in a high percentage of infected pigs, which may affect transmission and persistence of the virus in a herd.
AB - Objective-To determine the pattern of infection for porcine circovirus type 2 (PCV2) in a herd of pigs with postweaning multisystemic wasting syndrome (PMWS). Animals-29 sows and 250 pigs. Procedure-Blood samples were collected from all 3-, 7-, and 12-week old pigs and 59 pigs at 28 weeks of age. Pigs that died during the study were necropsied. Porcine parvovirus and PCV2 antibodies were assayed. A polymerase chain reaction (PCR) was used to detect PCV2 genome in serum of selected pigs. Results-The PMWS started when pigs were 8 weeks old, with a prevalence of 30% in 8- to 10-week-old pigs. Eighty-three pigs died during the period between 3 and 12 weeks of age. Microscopic lesions consistent with PMWS were observed, and PCV2 nucleic acid was detected (50 of 68 pigs). Antibodies to PCV2 decreased from 3 to 7 weeks of age, increased at 12 weeks of age, and were maintained until 28 weeks of age. One sow had a positive result for PCR of serum. Nine, 37, and 8 pigs had PCV2 genome in serum obtained at 7, 12, and 28 weeks of age, respectively. Conclusions and Clinical Relevance-Infection with PCV2 coincided with severe clinical signs; however, infected 28-week-old pigs did not have evidence of disease. Immunity declined over time in young pigs. A long duration of PCV2 viremia was apparent in a high percentage of infected pigs, which may affect transmission and persistence of the virus in a herd.
U2 - 10.2460/ajvr.2002.63.354
DO - 10.2460/ajvr.2002.63.354
M3 - Article
VL - 63
SP - 354
EP - 357
JO - American Journal of Veterinary Research
JF - American Journal of Veterinary Research
SN - 0002-9645
IS - 3
ER -