Dual-Fluorescent Nanoscale Coordination Polymers via a Mixed-Ligand Synthetic Strategy and Their Use for Multichannel Imaging

Fabiana Nador, Karolina Wnuk, Javier García-Pardo, Julia Lorenzo, Rubén Solorzano, Daniel Ruiz-Molina, Fernando Novio

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Abstract

© 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim Two rationally designed strategies for covalent bonding of fluorescent dyes in coordination polymer nanoparticles aiming to achieve bifunctional fluorescent nanostructures have been developed. The first strategy was based on the synthesis of the coordination polymers structured as nanoparticles by coordination of CoII ions to two different catechol ligands containing free functional chemical groups (dopamine and 3,4-dihydroxybenzaldehyde), and a bis(imidazole)-based ligand (1,4-bis(imidazole-1-ylmethyl)benzene, bix). Subsequently, different dyes, namely fluorescein isothiocyanate (FITC), 1-pyrenebutanoic acid hydrazide (PBH) or Alexa Fluor® 568 (A568), could be sequentially attached to the surface of the nanoparticles. The second strategy was focused on the prefunctionalization of catechol ligands with the corresponding dyes and, afterwards, the coordination with the metal ions in presence of bix. In vitro studies demonstrated the internalization of the bifunctional nanoparticles and the persistence of the fluorescent properties after cell uptake without dye leaching.
Original languageEnglish
Pages (from-to)183-193
JournalChemNanoMat
Volume4
Issue number2
DOIs
Publication statusPublished - 1 Feb 2018

Keywords

  • biosensors
  • catechol
  • coordination polymers
  • fluorescent probes
  • nanoparticles

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