DOT-ELISA for detection of phenolic glycolipid PGL-Tb1 and diacyl-trehalose antigens of Mycobacterium tuberculosis

F. Papa, M. Luquin, H. L. David

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15 Citations (Scopus)

Abstract

A DOT-ELISA method for detection of 2,3-diacyl-trehalose (DAT, previously referred to as SL-IV antigen) and triglycosyl phenol phthiocerol di-mycocerosate (PGL-Tb 1) antigens from Mycobacterium tuberculosis is described. The method enabled the detection of both antigens in 14 clinical isolates of M. tuberculosis from different geographic origins; the presence of the glycolipids was confirmed by chemical analysis. It was therefore concluded that the synthesis of both of these compounds is characteristic of the species. © 1992.
Original languageEnglish
Pages (from-to)327-331
JournalResearch in Microbiology
Volume143
Issue number3
DOIs
Publication statusPublished - 1 Jan 1992

Keywords

  • DAT
  • Détection
  • DOT-ELISA
  • Glycolipid
  • Mycobacterium tuberculosis
  • PGL-Tb1

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