Dopamine signaling in the striatum

Emmanuel Valjent, Anne Biever, Giuseppe Gangarossa, Emma Puighermanal

Research output: Chapter in BookChapterResearchpeer-review

5 Citations (Scopus)

Abstract

© 2019 Elsevier Inc. The striatum integrates dopamine-mediated reward signals to generate appropriate behavior in response to glutamate-mediated sensory cues. Such associative learning relies on enduring neural plasticity in striatal GABAergic spiny projection neurons which, when altered, can lead to the development of a wide variety of pathological states. Considerable progress has been made in our understanding of the intracellular signaling mechanisms in dopamine-related behaviors and pathologies. Through the prism of the regulation of histone H3 and ribosomal protein S6 phosphorylation, we review how dopamine-mediated signaling events regulate gene transcription and mRNA translation. Particularly, we focus on the intracellular cascades controlling these phosphorylations downstream of the modulation of dopamine receptors by psychostimulants, antipsychotics and L-DOPA. Finally, we highlight the importance to precisely determine in which neuronal populations these signaling events occur in order to understand how they participate in remodeling neural circuits and altering dopamine-related behaviors.
Original languageEnglish
Title of host publicationAdvances in Protein Chemistry and Structural Biology
Pages375-396
Number of pages21
Volume116
DOIs
Publication statusPublished - 1 Jan 2019

Keywords

  • Antipsychotics
  • Dopamine
  • Histone H3
  • Intracellular signaling cascades
  • Phosphorylation
  • Psychostimulants
  • Ribosomal protein S6
  • Striatum

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