TY - JOUR
T1 - Does practice make perfect?
T2 - Functional connectivity of the salience network and somatosensory network predicts response to mind-body treatments for fibromyalgia
AU - Medina, Sonia
AU - O'Daly, Owen
AU - Howard, Matthew A
AU - Feliu-Soler, Albert
AU - Luciano, Juan V
N1 - Publisher Copyright:
2024 Medina, O’Daly, Howard, Feliu-Soler and Luciano.
Publisher Copyright:
2024 Medina, O’Daly, Howard, Feliu-Soler and Luciano.
PY - 2024/9/5
Y1 - 2024/9/5
N2 - Background: Mind–body treatments can improve coping mechanisms to deal with pain, improve the quality of life of patients with fibromyalgia syndrome (FMS), and reduce perceived pain in some cases. However, responses to these treatments are highly variable, the mechanisms underpinning them remain unclear, and reliable predictors of treatment response are lacking. We employed resting-state blood oxygen level-dependent (rsBOLD) functional magnetic resonance imaging (fMRI) to examine changes in brain functional connectivity (FC) following mind–body treatment that may relate to and predict pain relief. Methods: We recruited patients with FMS who underwent either mindfulness-based stress reduction (MBSR; n = 18) or a psychoeducational program (FibroQoL; n = 22) and a treatment-as-usual FMS group (TAU; n = 18). We collected rsBOLD data, alongside subjective pain, anxiety, depression, and catastrophizing measures prior to and following treatments. We examined behavioral changes and FC changes in the salience network (SN) and sensorimotor network (SMN) and performed regression analyses to identify predictors for treatment response. Results: The MBSR and FibroQoL groups experienced significant reductions in pain catastrophizing. After treatment, the FC of the sensorimotor cortex with the rest of the SMN became significantly reduced in the MBSR group compared to the TAU group. The FC between the SN and the SMN at baseline was negatively correlated with pain reductions following MBSR but positively correlated with pain reductions in the FibroQoL group. These results yielded large to very large effect sizes. Following MBSR, only for those patients with lower baseline SMN-SN FC, minutes of mindfulness practice were positively associated with clinical improvement (small to medium effect size). Conclusions: Different mind–body treatments are underpinned by discrete brain networks. Measures of the functional interplay between SN and SMN have the potential as predictors of mind–body treatment response in patients with FMS.
AB - Background: Mind–body treatments can improve coping mechanisms to deal with pain, improve the quality of life of patients with fibromyalgia syndrome (FMS), and reduce perceived pain in some cases. However, responses to these treatments are highly variable, the mechanisms underpinning them remain unclear, and reliable predictors of treatment response are lacking. We employed resting-state blood oxygen level-dependent (rsBOLD) functional magnetic resonance imaging (fMRI) to examine changes in brain functional connectivity (FC) following mind–body treatment that may relate to and predict pain relief. Methods: We recruited patients with FMS who underwent either mindfulness-based stress reduction (MBSR; n = 18) or a psychoeducational program (FibroQoL; n = 22) and a treatment-as-usual FMS group (TAU; n = 18). We collected rsBOLD data, alongside subjective pain, anxiety, depression, and catastrophizing measures prior to and following treatments. We examined behavioral changes and FC changes in the salience network (SN) and sensorimotor network (SMN) and performed regression analyses to identify predictors for treatment response. Results: The MBSR and FibroQoL groups experienced significant reductions in pain catastrophizing. After treatment, the FC of the sensorimotor cortex with the rest of the SMN became significantly reduced in the MBSR group compared to the TAU group. The FC between the SN and the SMN at baseline was negatively correlated with pain reductions following MBSR but positively correlated with pain reductions in the FibroQoL group. These results yielded large to very large effect sizes. Following MBSR, only for those patients with lower baseline SMN-SN FC, minutes of mindfulness practice were positively associated with clinical improvement (small to medium effect size). Conclusions: Different mind–body treatments are underpinned by discrete brain networks. Measures of the functional interplay between SN and SMN have the potential as predictors of mind–body treatment response in patients with FMS.
KW - brain biomarker
KW - fibromyalgia
KW - functional connectivity
KW - mindfulness
KW - rsBOLD
KW - Brain biomarker
KW - Functional connectivity
KW - Fibromyalgia
KW - Mindfulness
UR - http://www.scopus.com/inward/record.url?scp=85204685699&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/6539074d-bdcb-36f6-ba4d-97e37295df16/
UR - https://portalrecerca.uab.cat/en/publications/0e756293-e92d-4f4f-8b57-9a86a36145f7
U2 - 10.3389/fpain.2024.1245235
DO - 10.3389/fpain.2024.1245235
M3 - Article
C2 - 39328273
SN - 2673-561X
VL - 5
JO - Frontiers in Pain Research
JF - Frontiers in Pain Research
M1 - 1245235
ER -