Does monosomy 5 really exist in myelodysplastic syndromes and acute myeloid leukemia?

Ana Belén Galván; Mar Mallo; Leonor Arenillas; Marta Salido; Blanca Espinet; Carmen Pedro; Lourdes Florensa; Sergi Serrano; Francesc Solé

doi:10.1016/j.leukres.2010.03.022

Does monosomy 5 really exist in myelodysplastic syndromes and acute myeloid leukemia?

Ana Belén Galván, Mar Mallo, Leonor Arenillas, Marta Salido, Blanca Espinet, Carmen Pedro, Lourdes Florensa, Sergi Serrano, Francesc Solé

Department of Morphological Sciences

Research output: Contribution to journal › Article › Research › peer-review

19 Citations (Scopus)

Abstract

Abnormalities of chromosome 5 are common aberrations in myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML), being del(5q) the most frequent. In contrast, monosomy 5 is not so frequent and, usually, is associated with complex karyotypes, conferring poor prognosis. The aim of this study was to analyze, by FISH for 5q31 (EGR1), a series of 28 MDS and AML cases with monosomy 5 detected by G-banding. FISH results revealed deletion of 5q31 in 24 of them (85.7%) and monosomy 5 just in three. FISH for 5q31 can complement conventional cytogenetics and improve the karyotype definition, leading to a better diagnostic and prognostic stratification. © 2010 Elsevier Ltd.

Original language	English
Pages (from-to)	1242-1245
Journal	Leukemia Research
Volume	34
Issue number	9
DOIs	https://doi.org/10.1016/j.leukres.2010.03.022
Publication status	Published - 1 Sep 2010

Keywords

5q deletion
Acute myeloid leukemia
FISH
Karyotype
Monosomy 5
Myelodysplastic syndrome

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10.1016/j.leukres.2010.03.022

Cite this

@article{8d324a7fc75a42748230ca6120f8fd9b,

title = "Does monosomy 5 really exist in myelodysplastic syndromes and acute myeloid leukemia?",

abstract = "Abnormalities of chromosome 5 are common aberrations in myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML), being del(5q) the most frequent. In contrast, monosomy 5 is not so frequent and, usually, is associated with complex karyotypes, conferring poor prognosis. The aim of this study was to analyze, by FISH for 5q31 (EGR1), a series of 28 MDS and AML cases with monosomy 5 detected by G-banding. FISH results revealed deletion of 5q31 in 24 of them (85.7%) and monosomy 5 just in three. FISH for 5q31 can complement conventional cytogenetics and improve the karyotype definition, leading to a better diagnostic and prognostic stratification. {\textcopyright} 2010 Elsevier Ltd.",

keywords = "5q deletion, Acute myeloid leukemia, FISH, Karyotype, Monosomy 5, Myelodysplastic syndrome",

author = "Galv{\'a}n, {Ana Bel{\'e}n} and Mar Mallo and Leonor Arenillas and Marta Salido and Blanca Espinet and Carmen Pedro and Lourdes Florensa and Sergi Serrano and Francesc Sol{\'e}",

year = "2010",

month = sep,

day = "1",

doi = "10.1016/j.leukres.2010.03.022",

language = "English",

volume = "34",

pages = "1242--1245",

journal = "Leukemia Research",

issn = "0145-2126",

publisher = "Elsevier Limited",

number = "9",

}