Does monosomy 5 really exist in myelodysplastic syndromes and acute myeloid leukemia?

Ana Belén Galván, Mar Mallo, Leonor Arenillas, Marta Salido, Blanca Espinet, Carmen Pedro, Lourdes Florensa, Sergi Serrano, Francesc Solé

Research output: Contribution to journal › Article › Research › peer-review

19 Citations (Scopus)

Abstract

Abnormalities of chromosome 5 are common aberrations in myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML), being del(5q) the most frequent. In contrast, monosomy 5 is not so frequent and, usually, is associated with complex karyotypes, conferring poor prognosis. The aim of this study was to analyze, by FISH for 5q31 (EGR1), a series of 28 MDS and AML cases with monosomy 5 detected by G-banding. FISH results revealed deletion of 5q31 in 24 of them (85.7%) and monosomy 5 just in three. FISH for 5q31 can complement conventional cytogenetics and improve the karyotype definition, leading to a better diagnostic and prognostic stratification. © 2010 Elsevier Ltd.
Original languageEnglish
Pages (from-to)1242-1245
JournalLeukemia Research
Volume34
Issue number9
DOIs
Publication statusPublished - 1 Sep 2010

Keywords

  • 5q deletion
  • Acute myeloid leukemia
  • FISH
  • Karyotype
  • Monosomy 5
  • Myelodysplastic syndrome

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