Do moonlighting proteins belong to the intrinsically disordered protein class?

Sergio Hernández, Isaac Amela, Juan Cedano, Jaume Piñol, Josep Antoni Perez-Pons, Angel Mozo-Villarias, Enrique Querol

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)


Moonlighting is the capability of some proteins to execute two or more biological functions. According to some authors, there is a relationship between protein conformational fluctuations and promiscuous functions of proteins. This promiscuity would be due to the conformational properties of the structurally disordered regions. To check if moonlighting proteins belong to the Intrinsically Disordered Protein (IDP) class, we have predicted IDP/IDR (Intrinsically Disordered Regions) for a number of moonlighting proteins. Our results suggest that most moonlighting proteins do not belong to the IDP class. © 2012 Hernández S, et al.
Original languageEnglish
Pages (from-to)262-264
JournalJournal of Proteomics and Bioinformatics
Issue number11
Publication statusPublished - 12 Dec 2012


  • Intrinsically disordered proteins
  • Intrinsically disordered regions
  • Moonlighting proteins
  • Multitasking proteins


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