Moonlighting is the capability of some proteins to execute two or more biological functions. According to some authors, there is a relationship between protein conformational fluctuations and promiscuous functions of proteins. This promiscuity would be due to the conformational properties of the structurally disordered regions. To check if moonlighting proteins belong to the Intrinsically Disordered Protein (IDP) class, we have predicted IDP/IDR (Intrinsically Disordered Regions) for a number of moonlighting proteins. Our results suggest that most moonlighting proteins do not belong to the IDP class. © 2012 Hernández S, et al.
|Journal||Journal of Proteomics and Bioinformatics|
|Publication status||Published - 12 Dec 2012|
- Intrinsically disordered proteins
- Intrinsically disordered regions
- Moonlighting proteins
- Multitasking proteins