Do low molecular weight agents cause more severe asthma than high molecular weight agents?

Olga Meca, María Jesús Cruz, Mónica Sánchez-Ortiz, Francisco Javier González-Barcala, Iñigo Ojanguren, Xavier Munoz

    Research output: Contribution to journalArticleResearchpeer-review

    15 Citations (Scopus)

    Abstract

    © 2016 Meca et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Introduction: The aim of this study was to analyse whether patients with occupational asthma (OA) caused by low molecular weight (LMW) agents differed from patients with OA caused by high molecular weight (HMW) with regard to risk factors, asthma presentation and severity, and response to various diagnostic tests. Methods: Seventy-eight patients with OA diagnosed by positive specific inhalation challenge (SIC) were included. Anthropometric characteristics, atopic status, occupation, latency periods, asthma severity according to the Global Initiative for Asthma (GINA) control classification, lung function tests and SIC results were analysed. Results: OA was induced by an HMW agent in 23 patients (29%) and by an LMW agent in 55 (71%). A logistic regression analysis confirmed that patients with OA caused by LMW agents had a significantly higher risk of severity according to the GINA classification after adjusting for potential confounders (OR = 3.579, 95% CI 1.136-11.280; p = 0.029). During the SIC, most patients with OA caused by HMW agents presented an early reaction (82%), while in patients with OA caused by LMW agents the response was mainly late (73%) (p = 0.0001). Similarly, patients with OA caused by LMW agents experienced a greater degree of bronchial hyperresponsiveness, measured as the difference in the methacholine dose-response ratio (DRR) before and after SIC (1.77, range 0-16), compared with patients with OA caused by HMW agents (0.87, range 0-72), (p = 0.024). Conclusions: OA caused by LMW agents may be more severe than that caused by HMW agents. The severity of the condition may be determined by the different mechanisms of action of these agents.
    Original languageEnglish
    Article numbere0156141
    JournalPLoS ONE
    Volume11
    Issue number6
    DOIs
    Publication statusPublished - 1 Jun 2016

    Fingerprint Dive into the research topics of 'Do low molecular weight agents cause more severe asthma than high molecular weight agents?'. Together they form a unique fingerprint.

  • Cite this

    Meca, O., Cruz, M. J., Sánchez-Ortiz, M., González-Barcala, F. J., Ojanguren, I., & Munoz, X. (2016). Do low molecular weight agents cause more severe asthma than high molecular weight agents? PLoS ONE, 11(6), [e0156141]. https://doi.org/10.1371/journal.pone.0156141