The interaction with DNA of two water soluble platinum supramolecular squares [(en)Pt(N-N)]4(NO3)8 (en = ethylenediamine, N-N = 1,4-bis(4-pyridyl)tetrafluorobenzene, compound 1, N-N = 4,4′-bipyridine, compound 2) has been studied by circular dichroism, electrophoretic mobility and atomic force microscopy. the two complexes drastically modify the second and tertiary structures of DNA, but compound 2 does it strongly due probably to its smaller size by comparison with compound 1 and its more suitable structural features for intercalation between base pairs. The two supramolecular squares were assayed against the HL-60 tumor cell line for 24 and 72 h. The IC50 values for 24 h are smaller than that of cisplatin for this time, however for 72 h the IC50 have higher values being the corresponding to compound 2 comparable to that of cisplatin. Apoptotic assays were also carried out for the compounds 1 and 2 against the tumor cell line. © 2007 Elsevier Inc. All rights reserved.
- Antitumor activity of Pt complexes
- Platinum macrocycle
- Pt complex-DNA intercalation
- Supramolecular chemistry
Mounir, M., Lorenzo, J., Ferrer, M., Prieto, M. J., Rossell, O., Avilès, F. X., & Moreno, V. (2007). DNA interaction and antiproliferative behavior of the water soluble platinum supramolecular squares [(en)Pt(N-N)]<inf>4</inf>(NO<inf>3</inf>)<inf>8</inf> (en = ethylenediamine, N-N = 4,4′-bipyridine or 1,4-bis(4-pyridyl)tetrafluorobenzene). Journal of Inorganic Biochemistry, 101, 660-666. https://doi.org/10.1016/j.jinorgbio.2006.12.009