DNA hypermethylation at the D17S5 locus is not a frequent event in human urothelial cancer

M. Bernués, C. Casadevall, M. R. Caballín, J. Egozcue, R. Miró

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Objective: To analyse the DNA methylation status and the loss of heterozygosity (LOH) at the D17S5 locus (17p13.3) in urothelial cancer. Materials and methods: DNA methylation was assayed and LOH analysed by Southern blotting in a series of 33 transitional cell carcinomas of the bladder and renal pelvis. Results: DNA hypermethylation and LOH at the D17S5 locus were detected in six (18%) and 17 (52%) of the tumours, respectively. The six cases with DNA hypermethylation were of the papillary type, and four also had LOH at this locus. Conclusion: In contrast to other epithelial tumours, DNA hypermethylation at the D17S5 locus is not a frequent event in human urothelial cancer.
Original languageEnglish
Pages (from-to)332-335
JournalBJU International
Volume90
DOIs
Publication statusPublished - 18 Sep 2002

Keywords

  • DNA methylation
  • Loss of heterozygosity
  • Tumour suppressor genes
  • Urothelial cancer

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