Divergent effects of isolation rearing on prepulse inhibition, activity, anxiety and hippocampal-dependent memory in Roman high- and low-avoidance rats: A putative model of schizophrenia-relevant features

Ignasi Oliveras, Ana Sánchez-González, Maria Antonietta Piludu, Cristina Gerboles, Cristóbal Río-Álamos, Adolf Tobeña, Alberto Fernández-Teruel

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Abstract

© 2016 Social isolation of rats induces a constellation of behavioral alterations known as “isolation syndrome” that are consistent with some of the positive and cognitive symptoms observed in schizophrenic patients. In the present study we have assessed whether isolation rearing of inbred Roman high-avoidance (RHA-I) and Roman low-avoidance (RLA-I) strains can lead to the appearance of some of the key features of the “isolation syndrome”, such as prepulse inhibition (PPI) deficits, increased anxious behavior, hyperactivity and memory/learning impairments. Compared to RLA-I rats, the results show that isolation rearing (IR) in RHA-I rats has a more profound impact, as they exhibit isolation-induced PPI deficits, increased anxiety, hyperactivity and long-term reference memory deficits, while isolated RLA-I rats only exhibit deficits in a spatial working memory task. These results give further support to the validity of RHA-I rats as a genetically-based model of schizophrenia relevant-symptoms.
Original languageEnglish
Pages (from-to)6-15
JournalBehavioural Brain Research
Volume314
DOIs
Publication statusPublished - 1 Nov 2016

Keywords

  • Genetically-based rat model
  • Isolation rearing
  • Prepulse inhibition
  • Roman high- and low-avoidance rats
  • Schizophrenia
  • Spatial learning/memory

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