TY - JOUR
T1 - Divergent effects of isolation rearing on prepulse inhibition, activity, anxiety and hippocampal-dependent memory in Roman high- and low-avoidance rats: A putative model of schizophrenia-relevant features
AU - Oliveras, Ignasi
AU - Sánchez-González, Ana
AU - Piludu, Maria Antonietta
AU - Gerboles, Cristina
AU - Río-Álamos, Cristóbal
AU - Tobeña, Adolf
AU - Fernández-Teruel, Alberto
PY - 2016/11/1
Y1 - 2016/11/1
N2 - © 2016 Social isolation of rats induces a constellation of behavioral alterations known as “isolation syndrome” that are consistent with some of the positive and cognitive symptoms observed in schizophrenic patients. In the present study we have assessed whether isolation rearing of inbred Roman high-avoidance (RHA-I) and Roman low-avoidance (RLA-I) strains can lead to the appearance of some of the key features of the “isolation syndrome”, such as prepulse inhibition (PPI) deficits, increased anxious behavior, hyperactivity and memory/learning impairments. Compared to RLA-I rats, the results show that isolation rearing (IR) in RHA-I rats has a more profound impact, as they exhibit isolation-induced PPI deficits, increased anxiety, hyperactivity and long-term reference memory deficits, while isolated RLA-I rats only exhibit deficits in a spatial working memory task. These results give further support to the validity of RHA-I rats as a genetically-based model of schizophrenia relevant-symptoms.
AB - © 2016 Social isolation of rats induces a constellation of behavioral alterations known as “isolation syndrome” that are consistent with some of the positive and cognitive symptoms observed in schizophrenic patients. In the present study we have assessed whether isolation rearing of inbred Roman high-avoidance (RHA-I) and Roman low-avoidance (RLA-I) strains can lead to the appearance of some of the key features of the “isolation syndrome”, such as prepulse inhibition (PPI) deficits, increased anxious behavior, hyperactivity and memory/learning impairments. Compared to RLA-I rats, the results show that isolation rearing (IR) in RHA-I rats has a more profound impact, as they exhibit isolation-induced PPI deficits, increased anxiety, hyperactivity and long-term reference memory deficits, while isolated RLA-I rats only exhibit deficits in a spatial working memory task. These results give further support to the validity of RHA-I rats as a genetically-based model of schizophrenia relevant-symptoms.
KW - Genetically-based rat model
KW - Isolation rearing
KW - Prepulse inhibition
KW - Roman high- and low-avoidance rats
KW - Schizophrenia
KW - Spatial learning/memory
U2 - 10.1016/j.bbr.2016.07.047
DO - 10.1016/j.bbr.2016.07.047
M3 - Article
VL - 314
SP - 6
EP - 15
JO - Behavioural Brain Research
JF - Behavioural Brain Research
SN - 0166-4328
ER -