Distribution of α<inf>3</inf>, α<inf>5</inf> and α(v) integrin subunits in mature and immature human oocytes

G. Capmany, M. Mart, J. Santaló, V. N. Bolton

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Abstract

The distribution of three integrin subunits, α3, α5 and α(v), in immature and mature human oocytes has been examined using immunofluorescence and confocal microscopy. The results demonstrate that both α5 and α(v) are present at the germinal vesicle stage, while α3 was only detected in oocytes after germinal vesicle breakdown, in metaphase I and II stage oocytes. The cortical concentration of integrin subunits α3 and α5 is consistent with their localization in the oolemma. In contrast, the homogeneous distribution of α(v) throughout the oocyte suggests the existence of cytoplasmic reservoirs of this protein in the oocyte.
Original languageEnglish
Pages (from-to)951-956
JournalMolecular Human Reproduction
Volume4
DOIs
Publication statusPublished - 1 Oct 1998

Keywords

  • Germinal vesicle
  • Integrins
  • Maturation
  • Oocyte

Fingerprint Dive into the research topics of 'Distribution of α<inf>3</inf>, α<inf>5</inf> and α(v) integrin subunits in mature and immature human oocytes'. Together they form a unique fingerprint.

Cite this