Distension of the ischemic region predicts increased ventricular fibrillation inducibility following coronary occlusion in swine

José A. Barrabés, Jaume Figueras, Jaume Candell-Riera, Luis Agulló, Javier Inserte, David Garcia-Dorado

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Abstract

Introduction and objectives: Distension of the ischemic region has been related to an increased incidence of spontaneous ventricular arrhythmias following coronary occlusion. This study analyzed whether regional ischemic distension predicts increased ventricular fibrillation inducibility after coronary occlusion in swine. Methods: In 18 anesthetized, open-chest pigs, the left anterior descending coronary artery was ligated for 60 min. Myocardial segment length in the ischemic region was monitored by means of ultrasonic crystals. Programmed stimulation was applied at baseline and then continuously between 10 and 60 min after coronary occlusion. Results: Coronary occlusion induced a rapid increase in end-diastolic length in the ischemic region, which reached 109.4% (0,9%) of baseline values 10 min after occlusion (P<.001). On average, 6.6 (0,5) stimulation protocols were completed and 5.4 (0,6) ventricular fibrillation episodes induced between 10 and 60 min of coronary occlusion. Neither baseline serum potassium levels nor the size of the ischemic region were significantly related to ventricular fibrillation inducibility. In contrast, the increase in end-diastolic length 10 min after coronary occlusion was associated directly (r=0,67; P=.002) with the number of induced ventricular fibrillation episodes and inversely (r=-0,55; P=.018) with the number of extrastimuli needed for ventricular fibrillation induction. Conclusions: Regional ischemic expansion predicts increased ventricular fibrillation inducibility following coronary occlusion. These results highlight the potential influence of mechanical factors, acting not only on the triggers but also on the substrate, in the genesis of malignant ventricular arrhythmias during acute ischemia. © 2012 Sociedad Española de Cardiología. Published by Elsevier España, S.L. All rights reserved.
Original languageEnglish
Pages (from-to)171-176
JournalRevista Espanola de Cardiologia
Volume66
Issue number3
DOIs
Publication statusPublished - 1 Mar 2013

Keywords

  • Arrhythmia
  • Basic research
  • Fibrillation
  • Myocardial infarction
  • Myocardial ischemia
  • Sudden death
  • Ventricular fibrillation

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    Barrabés, J. A., Figueras, J., Candell-Riera, J., Agulló, L., Inserte, J., & Garcia-Dorado, D. (2013). Distension of the ischemic region predicts increased ventricular fibrillation inducibility following coronary occlusion in swine. Revista Espanola de Cardiologia, 66(3), 171-176. https://doi.org/10.1016/j.recesp.2012.08.006