Dissociation of the hepatic insulin receptor favours its phosphorylation by casein kinase 2

Ramon Trujillo, Marta Jose, Maria Plana, Elena Molina, Emilio Itarte

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2 Citations (Scopus)

Abstract

The αβ heterodimeric form of untreated hepatic insulin receptor was a substrate for casein kinase 2, whereas the α2β2 heterotetramer was not. On the contrary, autophosphorylation was detected only in the heterotetramer. Dissociation of the receptor by treatment with dithiothreitol decreased its autophosphorylation but favoured phosphorylation of its β-subunit by casein kinase 2. © 1991.
Original languageEnglish
Pages (from-to)15-18
JournalFEBS Letters
Volume283
Issue number1
DOIs
Publication statusPublished - 20 May 1991

Keywords

  • Casein kinase 2
  • Insulin receptor
  • Protein phosphorylation
  • Rat liver

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