Dissociation between adrenocorticotropin and corticosterone responses to restraint after previous chronic exposure to stress

A. Armario; C. Restrepo; J. M. Castellanos; J. Balasch

doi:https://doi.org/10.1016/0024-3205(85)90304-2

Dissociation between adrenocorticotropin and corticosterone responses to restraint after previous chronic exposure to stress

A. Armario, C. Restrepo, J. M. Castellanos, J. Balasch

Research output: Contribution to journal › Article › Research › peer-review

111 Citations (Scopus)

Abstract

The effect on emotional reactivity produced by a model for chronic stress in which different types of acute stresses were randomly combined for 29 days was studied in adult male rats. Chronically stressed rats showed a slight decrease in body weight gain and an increase in relative adrenal weight. Chronic stress did not modify defecation rate but reduced exploratory activity in the holeboard. Neither basal nor acute-stress induced levels of adrenocorticotropin (ACTH) were modified by previous chronic stress. Likewise, basal corticosterone levels were similar in both groups. However, corticosterone response to acute restraint stress was higher in chronically stressed than in control rats. The mechanisms underlying the dissociation between ACTH and corticosterone as well as its possible implications are discussed. © 1985.

Original language	English
Pages (from-to)	2085-2092
Journal	Life Sciences
Volume	36
DOIs	https://doi.org/10.1016/0024-3205(85)90304-2
Publication status	Published - 3 Jun 1985

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Armario, A., Restrepo, C., Castellanos, J. M., & Balasch, J. (1985). Dissociation between adrenocorticotropin and corticosterone responses to restraint after previous chronic exposure to stress. Life Sciences, 36, 2085-2092. https://doi.org/10.1016/0024-3205(85)90304-2

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