Disposition kenetics of tylosin administered intravenously and intramuscularly to pigs

C. Prats; G. El Korchi; R. Francesch; M. Arboix; B. Pérez

doi:https://doi.org/10.1016/S0034-5288(02)00036-X

Disposition kenetics of tylosin administered intravenously and intramuscularly to pigs

C. Prats, G. El Korchi, R. Francesch, M. Arboix, B. Pérez

Research output: Contribution to journal › Article › Research › peer-review

19 Citations (Scopus)

Abstract

The distribution of tylosin was studied using a crossover design, in six pigs following i.v. and i.m. administration of 10 mg kg-1 b.w. Plasma samples were analysed by HPLC and UV absorbance detection. After i.v. administration, t1/2β was 271.3 min, Vd 14.6 L kg-1, Vss 9.7Lkg-1 and CL 26.8 mL min-1 kg-1. After i.m. administration, a Cmax, Of 1 μg mL-1 was reached at 90 min. Mean absorption time was 1988.7 min and bioavailability was 95%. © 2002 Elsevier Science Ltd. All rights reserved.

Original language	English
Pages (from-to)	141-144
Journal	Research in Veterinary Science
Volume	73
DOIs	https://doi.org/10.1016/S0034-5288(02)00036-X
Publication status	Published - 1 Jan 2002

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title = "Disposition kenetics of tylosin administered intravenously and intramuscularly to pigs",

abstract = "The distribution of tylosin was studied using a crossover design, in six pigs following i.v. and i.m. administration of 10 mg kg-1 b.w. Plasma samples were analysed by HPLC and UV absorbance detection. After i.v. administration, t1/2β was 271.3 min, Vd 14.6 L kg-1, Vss 9.7Lkg-1 and CL 26.8 mL min-1 kg-1. After i.m. administration, a Cmax, Of 1 μg mL-1 was reached at 90 min. Mean absorption time was 1988.7 min and bioavailability was 95%. {\textcopyright} 2002 Elsevier Science Ltd. All rights reserved.",

author = "C. Prats and {El Korchi}, G. and R. Francesch and M. Arboix and B. P{\'e}rez",

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doi = "https://doi.org/10.1016/S0034-5288(02)00036-X",

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T1 - Disposition kenetics of tylosin administered intravenously and intramuscularly to pigs

AU - Prats, C.

AU - El Korchi, G.

AU - Francesch, R.

AU - Arboix, M.

AU - Pérez, B.

PY - 2002/1/1

Y1 - 2002/1/1

N2 - The distribution of tylosin was studied using a crossover design, in six pigs following i.v. and i.m. administration of 10 mg kg-1 b.w. Plasma samples were analysed by HPLC and UV absorbance detection. After i.v. administration, t1/2β was 271.3 min, Vd 14.6 L kg-1, Vss 9.7Lkg-1 and CL 26.8 mL min-1 kg-1. After i.m. administration, a Cmax, Of 1 μg mL-1 was reached at 90 min. Mean absorption time was 1988.7 min and bioavailability was 95%. © 2002 Elsevier Science Ltd. All rights reserved.

AB - The distribution of tylosin was studied using a crossover design, in six pigs following i.v. and i.m. administration of 10 mg kg-1 b.w. Plasma samples were analysed by HPLC and UV absorbance detection. After i.v. administration, t1/2β was 271.3 min, Vd 14.6 L kg-1, Vss 9.7Lkg-1 and CL 26.8 mL min-1 kg-1. After i.m. administration, a Cmax, Of 1 μg mL-1 was reached at 90 min. Mean absorption time was 1988.7 min and bioavailability was 95%. © 2002 Elsevier Science Ltd. All rights reserved.

U2 - https://doi.org/10.1016/S0034-5288(02)00036-X

DO - https://doi.org/10.1016/S0034-5288(02)00036-X

M3 - Article

VL - 73

SP - 141

EP - 144

JO - Research in Veterinary Science

JF - Research in Veterinary Science

SN - 0034-5288

ER -