Disentangling complex mixtures of compounds with near-identical 1H and 13C NMR spectra using pure shift NMR spectroscopy

Laura Castañar, Raquel Roldán, Pere Clapés, Albert Virgili, Teodor Parella

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)

Abstract

© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. The thorough analysis of highly complex NMR spectra using pure shift NMR experiments is described. The enhanced spectral resolution obtained from modern 2D HOBS experiments incorporating spectral aliasing in the 13C indirect dimension enables the distinction of similar compounds exhibiting near-identical 1H and 13C NMR spectra. It is shown that a complete set of extremely small Δδ(1H) and Δδ(13C) values, even below the natural line width (1 and 5 ppb, respectively), can be simultaneously determined and assigned.
Original languageEnglish
Pages (from-to)7682-7685
JournalChemistry - A European Journal
Volume21
Issue number21
DOIs
Publication statusPublished - 18 May 2015

Keywords

  • homodecoupling
  • mixture analysis
  • NMR spectroscopy
  • pure shift NMR
  • spectral aliasing

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