Direct observation of two-electron Ag(I)/Ag(III) redox cycles in coupling catalysis

Marc Font, Ferran Acuña-Parés, Teodor Parella, Jordi Serra, Josep M. Luis, Julio Lloret-Fillol, Miquel Costas, Xavi Ribas

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    Abstract

    Silver is extensively used in homogeneous catalysis for organic synthesis owing to its Lewis acidity, and as a powerful one-electron oxidant. However, two-electron redox catalytic cycles, which are most common in noble metal organometallic reactivity, have never been considered. Here we show that a Ag(I)/Ag(III) catalytic cycle is operative in model C-O and C-C cross-coupling reactions. An aryl-Ag(III) species is unequivocally identified as an intermediate in the catalytic cycle and we provide direct evidence of aryl halide oxidative addition and C-N, C-O, C-S, C-C and C-halide bond-forming reductive elimination steps at monometallic silver centres. We anticipate our study as the starting point for expanding Ag(I)/Ag(III) redox chemistry into new methodologies for organic synthesis, resembling well-known copper or palladium cross-coupling catalysis. Furthermore, findings described herein provide unique fundamental mechanistic understanding on Ag-catalysed cross-coupling reactions and dismiss the generally accepted conception that silver redox chemistry can only arise from one-electron processes. © 2014 Macmillan Publishers Limited. All rights reserved.
    Original languageEnglish
    Article number4373
    JournalNature Communications
    Volume5
    DOIs
    Publication statusPublished - 11 Jul 2014

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    Font, M., Acuña-Parés, F., Parella, T., Serra, J., Luis, J. M., Lloret-Fillol, J., Costas, M., & Ribas, X. (2014). Direct observation of two-electron Ag(I)/Ag(III) redox cycles in coupling catalysis. Nature Communications, 5, [4373]. https://doi.org/10.1038/ncomms5373