Difluoroalkylation of Anilines via Photoinduced Methods

Research output: Contribution to journalArticleResearchpeer-review

1 Downloads (Pure)


The development of sustainable and mild protocols for the fluoroalkylation of organic backbones is of current interest in chemical organic synthesis. Herein, we present operationally simple and practical transition-metal-free methods for the preparation of difluoroalkyl anilines. First, a visible-light organophotocatalytic system working via oxidative quenching is described, providing access to a wide range of difluoroalkyl anilines under mild conditions. In addition, the formation of an unprecedented electron donor-acceptor (EDA) complex between anilines and ethyl difluoroiodoacetate is reported and exploited as an alternative, efficient, and straightforward strategy to prepare difluoroalkyl derivatives.

Original languageEnglish
Pages (from-to)12585–12596
Number of pages12
JournalJournal of Organic Chemistry
Issue number17
Early online date16 Aug 2023
Publication statusPublished - 1 Sept 2023


Dive into the research topics of 'Difluoroalkylation of Anilines via Photoinduced Methods'. Together they form a unique fingerprint.

Cite this