Diffuse large B-cell lymphoma with concordant bone marrow involvement has peculiar genomic profile and poor clinical outcome

Ekaterina Chigrinova, Michael Mian, Marta Scandurra, Timothy C. Greiner, Wing C. Chan, Julie M. Vose, Giorgio Inghirami, Annalisa Chiappella, Luca Baldini, Maurilio Ponzoni, Andrés J.M. Ferreri, Silvia Franceschetti, Gianluca Gaidano, Alessandra Tucci, Fabio Facchetti, Thierry Lazure, Olivier Lambotte, Santiago Montes-Moreno, Miguel A. Piris, Josep Fr NomdedeuSilvia Uccella, Paola M.V. Rancoita, Ivo Kwee, Emanuele Zucca, Francesco Bertoni

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    23 Citations (Scopus)

    Abstract

    Bone marrow (BM) involvement in diffuse large B-cell lymphoma (DLBCL) can be morphologically discordant from the primary tumor. Concordant BM infiltration has been shown associated with a poorer outcome in patients treated with CHOP. In order to evaluate tumor-related factors leading to BM involvement in DLBCL, we performed an integrated analysis of i) genomic profiles obtained with a high-density genome wide SNP-based arrays ii) immunomorphological and iii) clinical data from 133 patients uniformly treated with R-CHOP. BM infiltration was found in 27 of 133 (20%) cases; and it was concordant in 18/27 (67%) cases. Concordant infiltration, but not discordant, influenced negatively OS, PFS and DFS and was associated with higher serum LDH, lower CR and higher PD rates. No association with cell of origin was found between BM+ and BM- DLBCL. As compared with BM- cases, BM+ DLBCL showed absence of 7q gain. © 2010 John Wiley & Sons, Ltd.
    Original languageEnglish
    Pages (from-to)38-41
    JournalHematological Oncology
    Volume29
    Issue number1
    DOIs
    Publication statusPublished - 1 Mar 2011

    Keywords

    • Bone marrow
    • CGH
    • Chromosome 7
    • Lymphoma
    • Microarray
    • Prognosis
    • R-CHOP

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  • Cite this

    Chigrinova, E., Mian, M., Scandurra, M., Greiner, T. C., Chan, W. C., Vose, J. M., Inghirami, G., Chiappella, A., Baldini, L., Ponzoni, M., Ferreri, A. J. M., Franceschetti, S., Gaidano, G., Tucci, A., Facchetti, F., Lazure, T., Lambotte, O., Montes-Moreno, S., Piris, M. A., ... Bertoni, F. (2011). Diffuse large B-cell lymphoma with concordant bone marrow involvement has peculiar genomic profile and poor clinical outcome. Hematological Oncology, 29(1), 38-41. https://doi.org/10.1002/hon.953