Differential roles of antimicrobials in the acquisition of drug resistance through activation of the SOS response in Acinetobacter baumannii

Luis M. Jara, Pilar Cortés, Germán Bou, Jordi Barbé, Jesús Aranda

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Abstract

Copyright © 2015, American Society for Microbiology. All Rights Reserved. The effect of antimicrobials on SOS-mediated mutagenesis induction depends on the bacterial species and the antimicrobial group. In this work, we studied the effect of different families of antimicrobial agents used in clinical therapy against Acinetobacter baumannii in the induction of mutagenesis in this multiresistant Gram-negative pathogen. The data showed that ciprofloxacin and tetracycline induce SOS-mediated mutagenesis, whereas colistin and meropenem, which are extensively used in clinical therapy, do not.
Original languageEnglish
Pages (from-to)4318-4320
JournalAntimicrobial Agents and Chemotherapy
Volume59
Issue number7
DOIs
Publication statusPublished - 1 Jul 2015

Fingerprint

Dive into the research topics of 'Differential roles of antimicrobials in the acquisition of drug resistance through activation of the SOS response in Acinetobacter baumannii'. Together they form a unique fingerprint.

Cite this