The accumulation of histone H1o has been studied in neuronal and glial nuclei from rat cerebral cortex during postnatal development. In neurons H1o represents ∼2% of the H1 content at birth and remains unchanged until day 8. Beyond this point H1o accumulates rapidly until day 18, where it levels off at 16% of H1. The midpoint of the transition is at day 14. In glial cells H1o represents ∼2.5% of the H1 at birth. It starts to accumulate between days 18 and 21; its concentration raises rapidly up to day 30 slowing down from then on. At day 300 (the farthest point examined) it represents 21% of H1. These results are discussed in relation to the events of the postnatal development of the cerebral cortex in the rat. It is concluded that Ho probably does not suppress cell proliferation. © 1984.
|Journal||Biochemical and Biophysical Research Communications|
|Publication status||Published - 17 Sep 1984|