Differential expression of the Middle East respiratory syndrome coronavirus receptor in the upper respiratory tracts of humans and dromedary camels

W. Widagdo; V. Stalin Raj; Debby Schipper; Kimberley Kolijn; Geert J.L.H. Van Leenders; Berend J. Bosch; Albert Bensaid; Joaquim Segalés; Wolfgang Baumgärtner; Albert D.M.E. Osterhaus; Marion P. Koopmans; Judith M.A. Van Den Brand; Bart L. Haagmans

doi:10.1128/JVI.02994-15

Differential expression of the Middle East respiratory syndrome coronavirus receptor in the upper respiratory tracts of humans and dromedary camels

W. Widagdo, V. Stalin Raj, Debby Schipper, Kimberley Kolijn, Geert J.L.H. Van Leenders, Berend J. Bosch, Albert Bensaid, Joaquim Segalés, Wolfgang Baumgärtner, Albert D.M.E. Osterhaus, Marion P. Koopmans, Judith M.A. Van Den Brand, Bart L. Haagmans

Department of Animal Health and Anatomy

Research output: Contribution to journal › Article › Research › peer-review

51 Citations (Scopus)

Abstract

© 2016, American Society for Microbiology. All Rights Reserved. Middle East respiratory syndrome coronavirus (MERS-CoV) is not efficiently transmitted between humans, but it is highly prevalent in dromedary camels. Here we report that the MERS-CoV receptor-dipeptidyl peptidase 4 (DPP4)-is expressed in the upper respiratory tract epithelium of camels but not in that of humans. Lack of DPP4 expression may be the primary cause of limited MERS-CoV replication in the human upper respiratory tract and hence restrict transmission.

Original language	English
Pages (from-to)	4838-4842
Journal	Journal of Virology
Volume	90
Issue number	9
DOIs	https://doi.org/10.1128/JVI.02994-15
Publication status	Published - 1 May 2016

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Widagdo, W., Raj, V. S., Schipper, D., Kolijn, K., Van Leenders, G. J. L. H., Bosch, B. J., Bensaid, A., Segalés, J., Baumgärtner, W., Osterhaus, A. D. M. E., Koopmans, M. P., Van Den Brand, J. M. A., & Haagmans, B. L. (2016). Differential expression of the Middle East respiratory syndrome coronavirus receptor in the upper respiratory tracts of humans and dromedary camels. Journal of Virology, 90(9), 4838-4842. https://doi.org/10.1128/JVI.02994-15

Widagdo, W. ; Raj, V. Stalin ; Schipper, Debby ; Kolijn, Kimberley ; Van Leenders, Geert J.L.H. ; Bosch, Berend J. ; Bensaid, Albert ; Segalés, Joaquim ; Baumgärtner, Wolfgang ; Osterhaus, Albert D.M.E. ; Koopmans, Marion P. ; Van Den Brand, Judith M.A. ; Haagmans, Bart L. / Differential expression of the Middle East respiratory syndrome coronavirus receptor in the upper respiratory tracts of humans and dromedary camels. In: Journal of Virology. 2016 ; Vol. 90, No. 9. pp. 4838-4842.

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title = "Differential expression of the Middle East respiratory syndrome coronavirus receptor in the upper respiratory tracts of humans and dromedary camels",

abstract = "{\textcopyright} 2016, American Society for Microbiology. All Rights Reserved. Middle East respiratory syndrome coronavirus (MERS-CoV) is not efficiently transmitted between humans, but it is highly prevalent in dromedary camels. Here we report that the MERS-CoV receptor-dipeptidyl peptidase 4 (DPP4)-is expressed in the upper respiratory tract epithelium of camels but not in that of humans. Lack of DPP4 expression may be the primary cause of limited MERS-CoV replication in the human upper respiratory tract and hence restrict transmission.",

author = "W. Widagdo and Raj, {V. Stalin} and Debby Schipper and Kimberley Kolijn and {Van Leenders}, {Geert J.L.H.} and Bosch, {Berend J.} and Albert Bensaid and Joaquim Segal{\'e}s and Wolfgang Baumg{\"a}rtner and Osterhaus, {Albert D.M.E.} and Koopmans, {Marion P.} and {Van Den Brand}, {Judith M.A.} and Haagmans, {Bart L.}",

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Widagdo, W, Raj, VS, Schipper, D, Kolijn, K, Van Leenders, GJLH, Bosch, BJ, Bensaid, A, Segalés, J, Baumgärtner, W, Osterhaus, ADME, Koopmans, MP, Van Den Brand, JMA & Haagmans, BL 2016, 'Differential expression of the Middle East respiratory syndrome coronavirus receptor in the upper respiratory tracts of humans and dromedary camels', Journal of Virology, vol. 90, no. 9, pp. 4838-4842. https://doi.org/10.1128/JVI.02994-15

Differential expression of the Middle East respiratory syndrome coronavirus receptor in the upper respiratory tracts of humans and dromedary camels. / Widagdo, W.; Raj, V. Stalin; Schipper, Debby; Kolijn, Kimberley; Van Leenders, Geert J.L.H.; Bosch, Berend J.; Bensaid, Albert; Segalés, Joaquim; Baumgärtner, Wolfgang; Osterhaus, Albert D.M.E.; Koopmans, Marion P.; Van Den Brand, Judith M.A.; Haagmans, Bart L.

In: Journal of Virology, Vol. 90, No. 9, 01.05.2016, p. 4838-4842.

Research output: Contribution to journal › Article › Research › peer-review

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AU - Van Leenders, Geert J.L.H.

AU - Bosch, Berend J.

AU - Bensaid, Albert

AU - Segalés, Joaquim

AU - Baumgärtner, Wolfgang

AU - Osterhaus, Albert D.M.E.

AU - Koopmans, Marion P.

AU - Van Den Brand, Judith M.A.

AU - Haagmans, Bart L.

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N2 - © 2016, American Society for Microbiology. All Rights Reserved. Middle East respiratory syndrome coronavirus (MERS-CoV) is not efficiently transmitted between humans, but it is highly prevalent in dromedary camels. Here we report that the MERS-CoV receptor-dipeptidyl peptidase 4 (DPP4)-is expressed in the upper respiratory tract epithelium of camels but not in that of humans. Lack of DPP4 expression may be the primary cause of limited MERS-CoV replication in the human upper respiratory tract and hence restrict transmission.

AB - © 2016, American Society for Microbiology. All Rights Reserved. Middle East respiratory syndrome coronavirus (MERS-CoV) is not efficiently transmitted between humans, but it is highly prevalent in dromedary camels. Here we report that the MERS-CoV receptor-dipeptidyl peptidase 4 (DPP4)-is expressed in the upper respiratory tract epithelium of camels but not in that of humans. Lack of DPP4 expression may be the primary cause of limited MERS-CoV replication in the human upper respiratory tract and hence restrict transmission.

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