Abstract
© 2016, American Society for Microbiology. All Rights Reserved. Middle East respiratory syndrome coronavirus (MERS-CoV) is not efficiently transmitted between humans, but it is highly prevalent in dromedary camels. Here we report that the MERS-CoV receptor-dipeptidyl peptidase 4 (DPP4)-is expressed in the upper respiratory tract epithelium of camels but not in that of humans. Lack of DPP4 expression may be the primary cause of limited MERS-CoV replication in the human upper respiratory tract and hence restrict transmission.
Original language | English |
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Pages (from-to) | 4838-4842 |
Journal | Journal of Virology |
Volume | 90 |
Issue number | 9 |
DOIs | |
Publication status | Published - 1 May 2016 |