Differential expression of Kv1.3 and Kv1.5 voltage-dependent K + channels in human skeletal muscle sarcomas

Joanna Bielanska, Javier Hernández-Losa, Teresa Moline, Rosa Somoza, Santiago Ramón Y Cajal, Enric Condom, Joan Carles Ferreres, Antonio Felipe

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

Abstract

Because Kv1.3 and Kv1.5 K + channels are remodeled during tumorigenesis and participate in skeletal muscle proliferation, we analyzed their expression in human skeletal muscle sarcomas. Aggressive alveolar rhabdomyosarcoma (ARMS) and embryonal rhabdomyosarcoma (ERMS) were studied. Kv1.5 expression was moderate in adult muscle and low in ERMS, whereas it was notable in ARMS and embryonic samples. Kv1.3 expression showed no major differences between RMS and healthy samples. We found a correlation of Kv1.3 and Kv1.5 expression with the tumor malignancy. © 2012 Informa Healthcare USA, Inc.
Original languageEnglish
Pages (from-to)203-208
JournalCancer Investigation
Volume30
Issue number3
DOIs
Publication statusPublished - 1 Mar 2012

Keywords

  • Alveolar rhabdomyosarcomas
  • Cancer
  • Embryonal rhabdomyosarcomas
  • Potassium channels
  • Skeletal muscle

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