Differential expression of Kv1.3 and Kv1.5 voltage-dependent K + channels in human skeletal muscle sarcomas

Joanna Bielanska; Javier Hernández-Losa; Teresa Moline; Rosa Somoza; Santiago Ramón Y Cajal; Enric Condom; Joan Carles Ferreres; Antonio Felipe

doi:10.3109/07357907.2012.654872

Differential expression of Kv1.3 and Kv1.5 voltage-dependent K ⁺ channels in human skeletal muscle sarcomas

Joanna Bielanska, Javier Hernández-Losa, Teresa Moline, Rosa Somoza, Santiago Ramón Y Cajal, Enric Condom, Joan Carles Ferreres, Antonio Felipe

Department of Morphological Sciences

Research output: Contribution to journal › Article › Research › peer-review

14 Citations (Scopus)

Abstract

Because Kv1.3 and Kv1.5 K + channels are remodeled during tumorigenesis and participate in skeletal muscle proliferation, we analyzed their expression in human skeletal muscle sarcomas. Aggressive alveolar rhabdomyosarcoma (ARMS) and embryonal rhabdomyosarcoma (ERMS) were studied. Kv1.5 expression was moderate in adult muscle and low in ERMS, whereas it was notable in ARMS and embryonic samples. Kv1.3 expression showed no major differences between RMS and healthy samples. We found a correlation of Kv1.3 and Kv1.5 expression with the tumor malignancy. © 2012 Informa Healthcare USA, Inc.

Original language	English
Pages (from-to)	203-208
Journal	Cancer Investigation
Volume	30
Issue number	3
DOIs	https://doi.org/10.3109/07357907.2012.654872
Publication status	Published - 1 Mar 2012

Keywords

Alveolar rhabdomyosarcomas
Cancer
Embryonal rhabdomyosarcomas
Potassium channels
Skeletal muscle

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title = "Differential expression of Kv1.3 and Kv1.5 voltage-dependent K + channels in human skeletal muscle sarcomas",

abstract = "Because Kv1.3 and Kv1.5 K + channels are remodeled during tumorigenesis and participate in skeletal muscle proliferation, we analyzed their expression in human skeletal muscle sarcomas. Aggressive alveolar rhabdomyosarcoma (ARMS) and embryonal rhabdomyosarcoma (ERMS) were studied. Kv1.5 expression was moderate in adult muscle and low in ERMS, whereas it was notable in ARMS and embryonic samples. Kv1.3 expression showed no major differences between RMS and healthy samples. We found a correlation of Kv1.3 and Kv1.5 expression with the tumor malignancy. {\textcopyright} 2012 Informa Healthcare USA, Inc.",

keywords = "Alveolar rhabdomyosarcomas, Cancer, Embryonal rhabdomyosarcomas, Potassium channels, Skeletal muscle",

author = "Joanna Bielanska and Javier Hern{\'a}ndez-Losa and Teresa Moline and Rosa Somoza and {Ram{\'o}n Y Cajal}, Santiago and Enric Condom and Ferreres, {Joan Carles} and Antonio Felipe",

year = "2012",

month = mar,

day = "1",

doi = "10.3109/07357907.2012.654872",

language = "English",

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journal = "Cancer Investigation",

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Differential expression of Kv1.3 and Kv1.5 voltage-dependent K ⁺ channels in human skeletal muscle sarcomas. / Bielanska, Joanna; Hernández-Losa, Javier; Moline, Teresa; Somoza, Rosa; Ramón Y Cajal, Santiago; Condom, Enric; Ferreres, Joan Carles; Felipe, Antonio.

In: Cancer Investigation, Vol. 30, No. 3, 01.03.2012, p. 203-208.

Research output: Contribution to journal › Article › Research › peer-review

TY - JOUR

T1 - Differential expression of Kv1.3 and Kv1.5 voltage-dependent K + channels in human skeletal muscle sarcomas

AU - Bielanska, Joanna

AU - Hernández-Losa, Javier

AU - Moline, Teresa

AU - Somoza, Rosa

AU - Ramón Y Cajal, Santiago

AU - Condom, Enric

AU - Ferreres, Joan Carles

AU - Felipe, Antonio

PY - 2012/3/1

Y1 - 2012/3/1

N2 - Because Kv1.3 and Kv1.5 K + channels are remodeled during tumorigenesis and participate in skeletal muscle proliferation, we analyzed their expression in human skeletal muscle sarcomas. Aggressive alveolar rhabdomyosarcoma (ARMS) and embryonal rhabdomyosarcoma (ERMS) were studied. Kv1.5 expression was moderate in adult muscle and low in ERMS, whereas it was notable in ARMS and embryonic samples. Kv1.3 expression showed no major differences between RMS and healthy samples. We found a correlation of Kv1.3 and Kv1.5 expression with the tumor malignancy. © 2012 Informa Healthcare USA, Inc.

AB - Because Kv1.3 and Kv1.5 K + channels are remodeled during tumorigenesis and participate in skeletal muscle proliferation, we analyzed their expression in human skeletal muscle sarcomas. Aggressive alveolar rhabdomyosarcoma (ARMS) and embryonal rhabdomyosarcoma (ERMS) were studied. Kv1.5 expression was moderate in adult muscle and low in ERMS, whereas it was notable in ARMS and embryonic samples. Kv1.3 expression showed no major differences between RMS and healthy samples. We found a correlation of Kv1.3 and Kv1.5 expression with the tumor malignancy. © 2012 Informa Healthcare USA, Inc.

KW - Alveolar rhabdomyosarcomas

KW - Cancer

KW - Embryonal rhabdomyosarcomas

KW - Potassium channels

KW - Skeletal muscle

U2 - 10.3109/07357907.2012.654872

DO - 10.3109/07357907.2012.654872

M3 - Article

VL - 30

SP - 203

EP - 208

JO - Cancer Investigation

JF - Cancer Investigation

SN - 0735-7907

IS - 3

ER -