Differential effects of physostigmine and 1,2,3,4-tetrahydro-9-aminoacridine on the ß-adrenoceptor transduction system

Nuria M. Vivas; Albert Badia; Frederic Màrmol; Mara Dierssen

doi:10.1016/0922-4106(93)90163-4

Differential effects of physostigmine and 1,2,3,4-tetrahydro-9-aminoacridine on the ß-adrenoceptor transduction system

Nuria M. Vivas, Albert Badia, Frederic Màrmol, Mara Dierssen

Department of Pharmacology, Therapeutics and Toxicology

Research output: Contribution to journal › Article › Research › peer-review

5 Citations (Scopus)

Abstract

The effects of 1,2,3,4-tetrahydro-9-aminoacridine (THA) and physostigmine on ß-adrenoceptor-linked cyclic AMP accumulation have been analyzed in vitro in rat cortex and hippocampus. A 10-min incubation with increasing concentrations of THA reduced isoprenaline (10 μM)-stimulated cyclic AMP accumulation in a concentration-dependent manner in cortical (IC50 = 1.31 ± 0.13 μM) and hippocampal (IC50 = 0.02 ± 0.003 μM) structures. Conversely, physostigmine did not modify cyclic AMP synthesis in any experimental condition. The action of THA was non-competitive since it induced a non-parallel shift to the right of the concentration-response curve for isoprenaline. The differential effects of THA and physostigmine on the ß-adrenoceptor transduction system may account for the difference in their ability to restore cognitive function. © 1993.

Original language	English
Pages (from-to)	9-13
Journal	European Journal of Pharmacology: Molecular Pharmacology
Volume	245
Issue number	1
DOIs	https://doi.org/10.1016/0922-4106(93)90163-4
Publication status	Published - 15 Mar 1993

Keywords

Adenylate cyclase
cAMP
Cortex
Hippocampus
Physostigmine
ß-Adrenoceptors
Tetrahydroaminoacridine

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title = "Differential effects of physostigmine and 1,2,3,4-tetrahydro-9-aminoacridine on the {\ss}-adrenoceptor transduction system",

abstract = "The effects of 1,2,3,4-tetrahydro-9-aminoacridine (THA) and physostigmine on {\ss}-adrenoceptor-linked cyclic AMP accumulation have been analyzed in vitro in rat cortex and hippocampus. A 10-min incubation with increasing concentrations of THA reduced isoprenaline (10 μM)-stimulated cyclic AMP accumulation in a concentration-dependent manner in cortical (IC50 = 1.31 ± 0.13 μM) and hippocampal (IC50 = 0.02 ± 0.003 μM) structures. Conversely, physostigmine did not modify cyclic AMP synthesis in any experimental condition. The action of THA was non-competitive since it induced a non-parallel shift to the right of the concentration-response curve for isoprenaline. The differential effects of THA and physostigmine on the {\ss}-adrenoceptor transduction system may account for the difference in their ability to restore cognitive function. {\textcopyright} 1993.",

keywords = "Adenylate cyclase, cAMP, Cortex, Hippocampus, Physostigmine, {\ss}-Adrenoceptors, Tetrahydroaminoacridine",

author = "Vivas, \{Nuria M.\} and Albert Badia and Frederic M{\`a}rmol and Mara Dierssen",

year = "1993",

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doi = "10.1016/0922-4106(93)90163-4",

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T1 - Differential effects of physostigmine and 1,2,3,4-tetrahydro-9-aminoacridine on the ß-adrenoceptor transduction system

AU - Vivas, Nuria M.

AU - Badia, Albert

AU - Màrmol, Frederic

AU - Dierssen, Mara

PY - 1993/3/15

Y1 - 1993/3/15

N2 - The effects of 1,2,3,4-tetrahydro-9-aminoacridine (THA) and physostigmine on ß-adrenoceptor-linked cyclic AMP accumulation have been analyzed in vitro in rat cortex and hippocampus. A 10-min incubation with increasing concentrations of THA reduced isoprenaline (10 μM)-stimulated cyclic AMP accumulation in a concentration-dependent manner in cortical (IC50 = 1.31 ± 0.13 μM) and hippocampal (IC50 = 0.02 ± 0.003 μM) structures. Conversely, physostigmine did not modify cyclic AMP synthesis in any experimental condition. The action of THA was non-competitive since it induced a non-parallel shift to the right of the concentration-response curve for isoprenaline. The differential effects of THA and physostigmine on the ß-adrenoceptor transduction system may account for the difference in their ability to restore cognitive function. © 1993.

AB - The effects of 1,2,3,4-tetrahydro-9-aminoacridine (THA) and physostigmine on ß-adrenoceptor-linked cyclic AMP accumulation have been analyzed in vitro in rat cortex and hippocampus. A 10-min incubation with increasing concentrations of THA reduced isoprenaline (10 μM)-stimulated cyclic AMP accumulation in a concentration-dependent manner in cortical (IC50 = 1.31 ± 0.13 μM) and hippocampal (IC50 = 0.02 ± 0.003 μM) structures. Conversely, physostigmine did not modify cyclic AMP synthesis in any experimental condition. The action of THA was non-competitive since it induced a non-parallel shift to the right of the concentration-response curve for isoprenaline. The differential effects of THA and physostigmine on the ß-adrenoceptor transduction system may account for the difference in their ability to restore cognitive function. © 1993.

KW - Adenylate cyclase

KW - cAMP

KW - Cortex

KW - Hippocampus

KW - Physostigmine

KW - ß-Adrenoceptors

KW - Tetrahydroaminoacridine

UR - https://www.scopus.com/pages/publications/0027468207

U2 - 10.1016/0922-4106(93)90163-4

DO - 10.1016/0922-4106(93)90163-4

M3 - Article

SN - 0922-4106

VL - 245

SP - 9

EP - 13

JO - European Journal of Pharmacology: Molecular Pharmacology

JF - European Journal of Pharmacology: Molecular Pharmacology

IS - 1

ER -

Differential effects of physostigmine and 1,2,3,4-tetrahydro-9-aminoacridine on the ß-adrenoceptor transduction system

Abstract

Keywords

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