Differential effects of physostigmine and 1,2,3,4-tetrahydro-9-aminoacridine on the ß-adrenoceptor transduction system

Nuria M. Vivas, Albert Badia, Frederic Màrmol, Mara Dierssen

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Abstract

The effects of 1,2,3,4-tetrahydro-9-aminoacridine (THA) and physostigmine on ß-adrenoceptor-linked cyclic AMP accumulation have been analyzed in vitro in rat cortex and hippocampus. A 10-min incubation with increasing concentrations of THA reduced isoprenaline (10 μM)-stimulated cyclic AMP accumulation in a concentration-dependent manner in cortical (IC50 = 1.31 ± 0.13 μM) and hippocampal (IC50 = 0.02 ± 0.003 μM) structures. Conversely, physostigmine did not modify cyclic AMP synthesis in any experimental condition. The action of THA was non-competitive since it induced a non-parallel shift to the right of the concentration-response curve for isoprenaline. The differential effects of THA and physostigmine on the ß-adrenoceptor transduction system may account for the difference in their ability to restore cognitive function. © 1993.
Original languageEnglish
Pages (from-to)9-13
JournalEuropean Journal of Pharmacology: Molecular Pharmacology
Volume245
Issue number1
DOIs
Publication statusPublished - 15 Mar 1993

Keywords

  • Adenylate cyclase
  • cAMP
  • Cortex
  • Hippocampus
  • Physostigmine
  • ß-Adrenoceptors
  • Tetrahydroaminoacridine

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