Differential effects of cohort removal stress on the acoustic startle response of the Roman/Verh rat strains

R. Aguilar; L. Gil; A. Tobeña; R. M. Escorihuela; A. Fernández-Teruel

doi:https://doi.org/10.1023/A:1002042711672

Differential effects of cohort removal stress on the acoustic startle response of the Roman/Verh rat strains

R. Aguilar, L. Gil, A. Tobeña, R. M. Escorihuela, A. Fernández-Teruel

Department of Psychiatry and Legal Medicine

Research output: Contribution to journal › Article › Research › peer-review

21 Citations (Scopus)

Abstract

Male and female rats of the inbred Roman/Verh strains, which have been psychogenetically selected and bred for good (RHA-I/Verh) and extremely poor (RLA-I/Verh) two-way avoidance acquisition, were evaluated in an acoustic startle response test. One half of the rats of each strain and sex were previously subjected to 30 min of isolation by removal of their cage partners ('cohort removal'). During the testing session each animal received 40 acoustic stimuli at interstimulus intervals of 30 seconds. The hyperemotional RLA-I/Verh rats (especially the males) showed stronger acoustic startle responses than did their RHA-I/Verh counterparts. Startle amplitudes of the RLA-I/Verh males were further enhanced by the stress of 30 min isolation, whereas cohort removal did not significantly affect startle response amplitudes in RHA-I/Verh rats of either sex or in females of the RLA-I/Verh strain.

Original language	English
Pages (from-to)	71-75
Journal	Behavior Genetics
Volume	30
DOIs	https://doi.org/10.1023/A:1002042711672
Publication status	Published - 15 Aug 2000

Keywords

Acoustic startle responses
Amygdala
Anxiety
Cohort removal
Emotionality
Genetic selection
Isolation stress

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title = "Differential effects of cohort removal stress on the acoustic startle response of the Roman/Verh rat strains",

abstract = "Male and female rats of the inbred Roman/Verh strains, which have been psychogenetically selected and bred for good (RHA-I/Verh) and extremely poor (RLA-I/Verh) two-way avoidance acquisition, were evaluated in an acoustic startle response test. One half of the rats of each strain and sex were previously subjected to 30 min of isolation by removal of their cage partners ('cohort removal'). During the testing session each animal received 40 acoustic stimuli at interstimulus intervals of 30 seconds. The hyperemotional RLA-I/Verh rats (especially the males) showed stronger acoustic startle responses than did their RHA-I/Verh counterparts. Startle amplitudes of the RLA-I/Verh males were further enhanced by the stress of 30 min isolation, whereas cohort removal did not significantly affect startle response amplitudes in RHA-I/Verh rats of either sex or in females of the RLA-I/Verh strain.",

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author = "R. Aguilar and L. Gil and A. Tobe{\~n}a and Escorihuela, {R. M.} and A. Fern{\'a}ndez-Teruel",

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doi = "https://doi.org/10.1023/A:1002042711672",

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AU - Aguilar, R.

AU - Gil, L.

AU - Tobeña, A.

AU - Escorihuela, R. M.

AU - Fernández-Teruel, A.

PY - 2000/8/15

Y1 - 2000/8/15

N2 - Male and female rats of the inbred Roman/Verh strains, which have been psychogenetically selected and bred for good (RHA-I/Verh) and extremely poor (RLA-I/Verh) two-way avoidance acquisition, were evaluated in an acoustic startle response test. One half of the rats of each strain and sex were previously subjected to 30 min of isolation by removal of their cage partners ('cohort removal'). During the testing session each animal received 40 acoustic stimuli at interstimulus intervals of 30 seconds. The hyperemotional RLA-I/Verh rats (especially the males) showed stronger acoustic startle responses than did their RHA-I/Verh counterparts. Startle amplitudes of the RLA-I/Verh males were further enhanced by the stress of 30 min isolation, whereas cohort removal did not significantly affect startle response amplitudes in RHA-I/Verh rats of either sex or in females of the RLA-I/Verh strain.

AB - Male and female rats of the inbred Roman/Verh strains, which have been psychogenetically selected and bred for good (RHA-I/Verh) and extremely poor (RLA-I/Verh) two-way avoidance acquisition, were evaluated in an acoustic startle response test. One half of the rats of each strain and sex were previously subjected to 30 min of isolation by removal of their cage partners ('cohort removal'). During the testing session each animal received 40 acoustic stimuli at interstimulus intervals of 30 seconds. The hyperemotional RLA-I/Verh rats (especially the males) showed stronger acoustic startle responses than did their RHA-I/Verh counterparts. Startle amplitudes of the RLA-I/Verh males were further enhanced by the stress of 30 min isolation, whereas cohort removal did not significantly affect startle response amplitudes in RHA-I/Verh rats of either sex or in females of the RLA-I/Verh strain.

KW - Acoustic startle responses

KW - Amygdala

KW - Anxiety

KW - Cohort removal

KW - Emotionality

KW - Genetic selection

KW - Isolation stress

U2 - https://doi.org/10.1023/A:1002042711672

DO - https://doi.org/10.1023/A:1002042711672

M3 - Article

SN - 0001-8244

VL - 30

SP - 71

EP - 75

JO - Behavior Genetics

JF - Behavior Genetics

ER -

Differential effects of cohort removal stress on the acoustic startle response of the Roman/Verh rat strains

Abstract

Keywords

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