Differential effects of chronic treatment with mianserin and protryptiline on rat brain cortical α1-adrenoceptors

Joan Sallés, Enrique Claro, Agustina Garciá, Fernando Picatoste, Albert Badia

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Abstract

Chronic administration of mianserin induced an increase in the density of [3H]prazosin binding sites (23%) in membranes and in the maximal noradrenaline stimulation of phosphoinositide breakdown (81%) in slices from rat brain cortex. In contrast, a similar treatment with protryptiline did not induce any significant changes. These findings suggest that the effects of antidepressant drugs on rat braint cortical α1-adrenoceptors may depend on the characteristics of the drug used. © 1989.
Original languageEnglish
Pages (from-to)366-370
JournalBrain Research
Volume498
DOIs
Publication statusPublished - 2 Oct 1989

Keywords

  • Adrenoceptor
  • Cerebral cortex
  • Mianserin
  • Phosphoinositide hydrolysis
  • Prazosin binding
  • Protryptiline
  • α 1

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