Different receptors mediate stimulation of nitric oxide-dependent cyclic GMP formation in neurons and astrocytes in culture

Luis Agulló, Agustina García

Research output: Contribution to journalArticleResearchpeer-review

84 Citations (Scopus)

Abstract

The ability of various compounds to stimulate cyclic GMP accumulation was studied in neuronal and astrocyte-enriched primary cultures from rat cerebrum. Glutamate was the only agonist eliciting a response in neurons whereas several agonists had an effect in astrocytes but only those due to norepinephrine and glutamate were of considerable magnitude. The responses were markedly inhibited by the nitric oxide synthase inhibitor NG-monomethyl-L-arginine. The effect of glutamate appears to be mediated predominantly by NMDA receptors in neurons and by quisqualate AMPA-insensitive receptors in astrocytes. © 1992.
Original languageEnglish
Pages (from-to)1362-1368
JournalBiochem. biophys. res. commun.
Volume182
Issue number3
DOIs
Publication statusPublished - 14 Feb 1992

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