Different prognosis according to different clinical, electrocardiographic and scintigraphic ischemia criteria

Guillermo Romero-Farina, Jaume Candell-Riera, Santiago Aguadé-Bruix, María N. Pizzi, David García-Dorado

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4 Citations (Scopus)


© 2016 Elsevier Ireland Ltd. Background To analyse prognosis according to different clinical, electrocardiographic and scintigraphic responses on stress myocardial perfusion scintigraphy. Methods 3579 consecutive patients (age 63.1 ± 12; women: 46.8%) without known coronary artery disease were evaluated with a stress-rest myocardial perfusion single photon emission computed tomography (SPECT). In accordance with clinical (chest pain: ChP), electrocardiographic (ST +) and scintigraphic (SPECT +) ischemia criteria, patients were divided into 5 groups: Group 1 (n = 1902; with normal exercise test and SPECT without ChP); Group 2 (n = 456): ChP -, ST + and SPECT -; Group 3 (n = 594): ChP - and SPECT +; Group 4 (n = 444): ChP + and SPECT -; and Group 5 (n = 183): ChP + and SPECT +. Results During a follow-up of 5.1 ± 3.4 years, cardiac events (CE: cardiac mortality or nonfatal myocardial infarction) were significantly higher in groups 2 to 5 than in group 1 (p < 0.001). There was a trend to increased CE in patients with silent myocardial ischemia (SMI: Groups 2 and 3) vs symptomatic ischemia (Groups 4 and 5). Predictive value for CE of patients with SMI was HR: 3.1 (95%CI:2.1-4.4), and HR: 2.4 (95%CI:1.5-3.7) of patients with symptomatic ischemia. SMI was observed in 34.6% of diabetic patients vs 28.1% in nondiabetic patients (p = 0.001). Prognosis of patients with ST + plus SPECT + was significantly worse than patients with only ST + or only SPECT + (HR: 1.7, p = 0.026). Conclusions SMI has incremental prognostic value over clinical variables and symptomatic ischemia. In the context of SMI, a similar prognosis was observed between patients with only ST + and patients with only SPECT +, but significant worse prognosis was observed in patients with ST + plus SPECT +.
Original languageEnglish
Pages (from-to)240-246
JournalInternational Journal of Cardiology
Publication statusPublished - 15 Sep 2016


  • Cardiac events
  • Gated SPECT
  • Myocardial perfusion ischemia
  • Silent myocardial ischemia
  • ST segment depression


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