Differences in the CKD-EPI equation with MDRD for the estimation of glomerular filtration in hypertensive patients

M. A. Gómez Marcos, E. Rodríguez Sánchez, J. I. Recio Rodríguez, C. Martín Cantera, R. Ramos Blanes, L. García Ortiz

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8 Citations (Scopus)

Abstract

Objective: To analyze the agreement in glomerular filtration rate (GFR) estimated with CKD-EPI and MDRD-IDMS equations in a cohort of hypertensive patients. Methods: We included consecutively 478 hypertensive patients, 57.58 (SD: 12.34) aged, 68.3% males. The estimation of GFR was performed with MDRD-IDMS and CKD-EPI equations and we analyzed the agreement between them. Results: The estimation of GFR with CKD-EPI was 4.37 (95%:3,73-4,19) mL/min/1,73 m2higher than MDRD-IDMS, overall and by gender (males 3.99; females 5.04). In patients under 65 years the difference was greater, 6.55 (95%: 5,95-7,15) ml/min/1,73 m2in both men 6.07 and women 6.48. However, in over 65 years we found no significant difference. Intraclass correlation coefficient was 0.904 (95%CI: 0,886-0,919), 0.897 men and 0.917 women and Kappa index 0.848 (95% CI: 0.795-0.889), 0.845 men and 0.852 women. Conclusion: CKD-EPI equation estimated a higher FG in hypertensive patients under 65 years and reclassified in stage 1 patients classified in stage 2 by MDRD-IDMS. © 2010 Revista Nefrología.
Original languageEnglish
Pages (from-to)458-462
JournalNefrologia
Volume30
DOIs
Publication statusPublished - 31 Aug 2010

Keywords

  • Blood pressure
  • Calibration
  • Creatinine
  • Diagnosis
  • Epidemiology
  • Glomerular filtration rate
  • Kidney diseases

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