Differences in cardiovascular mortality in smokers, past-smokers and non-smokers. Findings from the FRENA registry

J. M. Suriñach, L. R. Álvarez, R. Coll, J. A. Carmona, C. Sanclemente, E. Aguilar, M. Monreal

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

Abstract

Background: The influence of smoking on outcome in patients with coronary artery disease (CAD) is controversial. Even less is known about its influence in patients with cerebrovascular (CVD), or peripheral artery (PAD) disease. Patients and methods: FRENA is an ongoing, observational registry of consecutive outpatients with symptomatic CAD, CVD, or PAD. We reviewed their cardiovascular mortality according to smoking status. Results: As of May 2008, 2501 patients had been enrolled in FRENA. Of these, 439 (18%) were current smokers, 1086 (43%) past-smokers, 976 (39%) had never smoked. Current- and past-smokers were 10 years younger, more often males, and more likely to have chronic lung disease, but had diabetes, hypertension, heart failure, or renal insufficiency less often than non-smokers. Over a mean follow-up of 14 months, 123 patients died (cardiovascular death, 68). On univariate analysis, current smokers had a significantly lower rate of cardiovascular death: 1.1 (95% CI: 0.4-2.4) per 100 patient-years in current smokers; 1.9 (95% CI: 1.2-2.8) in past-smokers; 3.5 (95% CI: 2.5-4.7) in non-smokers, with no differences between patients with CAD, CVD or PAD. Mean age at cardiovascular death was 82 ± 6.4; 70 ± 9.9 and 67 ± 15 years, respectively. On multivariate analysis, smoking status was not independently associated with a lower risk for cardiovascular death. Conclusions: Current and past-smokers with CAD, CVD or PAD had a less than half cardiovascular mortality than those who never smoked, but this may be explained by the confounding effect of additional variables. They died over 10 years younger than non-smokers. © 2009 European Federation of Internal Medicine.
Original languageEnglish
Pages (from-to)522-526
JournalEuropean Journal of Internal Medicine
Volume20
Issue number5
DOIs
Publication statusPublished - 1 Sep 2009

Keywords

  • Arterial disease
  • Outcome
  • Secondary prevention
  • Smoking

Fingerprint Dive into the research topics of 'Differences in cardiovascular mortality in smokers, past-smokers and non-smokers. Findings from the FRENA registry'. Together they form a unique fingerprint.

Cite this