Differences between en bloc resection and enucleation of retroperitoneal sarcomas

José Antonio Gonzalez Lopez, Vicente Artigas Raventós, Manuel Rodríguez Blanco, Antonio Lopez-Pousa, Silvia Bagué, Miriam Abellán, Manel Trias Folch

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)


© 2013 AEC. Aim: Today, free margin surgery is the gold-standard management for soft-tissue sarcoma patients and one of the most important predictors of recurrence and survival. To obtain optimal results, a multidisciplinary approach is necessary. The aim of this study was to evaluate the evolution of patients with RPS treated by en blocsurgical resection versus those treated with enucleation in the first surgery. Methods: Fifty-six adult patients were divided into 2 groups. Patients in Group A underwent enucleation surgery, and patients in Group B underwent en bloc surgery. The endpoints of the study were survival time and time to recurrence, according to histological type and first surgical strategy. Results: Disease-free survival was longer for en bloc surgery (P<0,05), but there was no difference in overall survival. When comparing the histology of patients who underwent enucleation surgery and en bloc resection surgery, the disease-free survival and overall survival rates were longer for liposarcoma. In the multivariate analysis, only free margins and histology of liposarcoma were significantly associated with a better survival. Conclusions: The surgical management of patients with retroperitoneal sarcoma must be very aggressive, often requiring multivisceral resection. Considering the disease-free survival and overall survival rates obtained, it is clear that it is critical to manage patients as early as possible by a radical en bloc surgery.
Original languageEnglish
Pages (from-to)525-531
JournalCirugia Espanola
Issue number8
Publication statusPublished - 1 Jan 2014


  • En bloc resection
  • Multidisciplinary management
  • Retroperitoneal sarcoma


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