Differences among pollen-allergic patients with and without plant food allergy

Javier Cuesta-Herranz, Domingo Barber, Carlos Blanco, Ana Cistero-Bahíma, Jesús F. Crespo, Montserrat Fernández-Rivas, Javier Fernández-Sánchez, J. Fernando Florido, M. Dolores Ibáñez, Rosalía Rodríguez, Gabriel Salcedo, Blanca E. Garcia, Manuel Lombardero, Joaquin Quiralte, Julia Rodriguez, Rosa Sánchez-Monge, Andrea Vereda, Mayte Villalba, M. Dolores Alonso Díaz De Durana, Maria BasagañaTeresa Carrillo, Mar Fernández-Nieto, Ana I. Tabar

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    Background: A considerable number of pollen-allergic patients develops allergy to plant foods, which has been attributed to cross-reactivity between food and pollen allergens. The aim of this study was to analyze the differences among pollen-allergic patients with and without plant food allergy. Methods: Eight hundred and six patients were recruited from 8 different hospitals. Each clinical research group included 100 patients (50 plant food-allergic patients and 50 pollen-allergic patients). Diagnosis of pollen allergy was based on typical case history of pollen allergy and positive skin prick tests. Diagnosis of plant-food allergy was based on clear history of plant-food allergy, skin prick tests and/or plant-food challenge tests. A panel of 28 purified allergens from pollens and/or plant foods was used to quantify specific IgE (ADVIA-Centaur® platform). Results: Six hundred and sixty eight patients (83%) of the 806 evaluated had pollen allergy: 396 patients with pollen allergy alone and 272 patients with associated food and pollen allergies. A comparison of both groups showed a statistically significant increase in the food and pollen allergy subgroup in frequency of: (1) asthma (47 vs. 59%; p < 0.001); (2) positive skin test results to several pollens: Plantago,Platanus,Artemisia, Betula,Parietaria and Salsola (p < 0.001); (3) sensitization to purified allergens: Pru p 3, profilin, Pla a 1 - Pla a 2, Sal k 1, PR-10 proteins and Len c 1. Conclusion: Results showed relevant and significant differences between both groups of pollen-allergic patients depending on whether or not they suffered from plant-derived food allergy. Copyright © 2010 S. Karger AG, Basel.
    Original languageEnglish
    Pages (from-to)182-192
    JournalInternational Archives of Allergy and Immunology
    Issue number2
    Publication statusPublished - 1 Sep 2010


    • Asthma
    • Component-resolved diagnostics
    • Immunotherapy
    • Plant food allergy
    • Pollen allergy
    • Profilin
    • Pru p 3


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