TY - JOUR
T1 - Differences among pollen-allergic patients with and without plant food allergy
AU - Cuesta-Herranz, Javier
AU - Barber, Domingo
AU - Blanco, Carlos
AU - Cistero-Bahíma, Ana
AU - Crespo, Jesús F.
AU - Fernández-Rivas, Montserrat
AU - Fernández-Sánchez, Javier
AU - Florido, J. Fernando
AU - Ibáñez, M. Dolores
AU - Rodríguez, Rosalía
AU - Salcedo, Gabriel
AU - Garcia, Blanca E.
AU - Lombardero, Manuel
AU - Quiralte, Joaquin
AU - Rodriguez, Julia
AU - Sánchez-Monge, Rosa
AU - Vereda, Andrea
AU - Villalba, Mayte
AU - Alonso Díaz De Durana, M. Dolores
AU - Basagaña, Maria
AU - Carrillo, Teresa
AU - Fernández-Nieto, Mar
AU - Tabar, Ana I.
PY - 2010/9/1
Y1 - 2010/9/1
N2 - Background: A considerable number of pollen-allergic patients develops allergy to plant foods, which has been attributed to cross-reactivity between food and pollen allergens. The aim of this study was to analyze the differences among pollen-allergic patients with and without plant food allergy. Methods: Eight hundred and six patients were recruited from 8 different hospitals. Each clinical research group included 100 patients (50 plant food-allergic patients and 50 pollen-allergic patients). Diagnosis of pollen allergy was based on typical case history of pollen allergy and positive skin prick tests. Diagnosis of plant-food allergy was based on clear history of plant-food allergy, skin prick tests and/or plant-food challenge tests. A panel of 28 purified allergens from pollens and/or plant foods was used to quantify specific IgE (ADVIA-Centaur® platform). Results: Six hundred and sixty eight patients (83%) of the 806 evaluated had pollen allergy: 396 patients with pollen allergy alone and 272 patients with associated food and pollen allergies. A comparison of both groups showed a statistically significant increase in the food and pollen allergy subgroup in frequency of: (1) asthma (47 vs. 59%; p < 0.001); (2) positive skin test results to several pollens: Plantago,Platanus,Artemisia, Betula,Parietaria and Salsola (p < 0.001); (3) sensitization to purified allergens: Pru p 3, profilin, Pla a 1 - Pla a 2, Sal k 1, PR-10 proteins and Len c 1. Conclusion: Results showed relevant and significant differences between both groups of pollen-allergic patients depending on whether or not they suffered from plant-derived food allergy. Copyright © 2010 S. Karger AG, Basel.
AB - Background: A considerable number of pollen-allergic patients develops allergy to plant foods, which has been attributed to cross-reactivity between food and pollen allergens. The aim of this study was to analyze the differences among pollen-allergic patients with and without plant food allergy. Methods: Eight hundred and six patients were recruited from 8 different hospitals. Each clinical research group included 100 patients (50 plant food-allergic patients and 50 pollen-allergic patients). Diagnosis of pollen allergy was based on typical case history of pollen allergy and positive skin prick tests. Diagnosis of plant-food allergy was based on clear history of plant-food allergy, skin prick tests and/or plant-food challenge tests. A panel of 28 purified allergens from pollens and/or plant foods was used to quantify specific IgE (ADVIA-Centaur® platform). Results: Six hundred and sixty eight patients (83%) of the 806 evaluated had pollen allergy: 396 patients with pollen allergy alone and 272 patients with associated food and pollen allergies. A comparison of both groups showed a statistically significant increase in the food and pollen allergy subgroup in frequency of: (1) asthma (47 vs. 59%; p < 0.001); (2) positive skin test results to several pollens: Plantago,Platanus,Artemisia, Betula,Parietaria and Salsola (p < 0.001); (3) sensitization to purified allergens: Pru p 3, profilin, Pla a 1 - Pla a 2, Sal k 1, PR-10 proteins and Len c 1. Conclusion: Results showed relevant and significant differences between both groups of pollen-allergic patients depending on whether or not they suffered from plant-derived food allergy. Copyright © 2010 S. Karger AG, Basel.
KW - Asthma
KW - Component-resolved diagnostics
KW - Immunotherapy
KW - Plant food allergy
KW - Pollen allergy
KW - Profilin
KW - Pru p 3
U2 - 10.1159/000312636
DO - 10.1159/000312636
M3 - Article
VL - 153
SP - 182
EP - 192
JO - International Archives of Allergy and Immunology
JF - International Archives of Allergy and Immunology
SN - 1018-2438
IS - 2
ER -