Dietary treatment of colic caused by excess gas in infants: Biochemical evidence

Dámaso Infante, Oscar Segarra, Bernard le Luyer

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)


AIM: To evaluate the impact of feeding colicky infants with an adapted formula on the hydrogen breath test and clinical symptoms. METHODS: Hydrogen expiration was measured by SC MicroLyzer gas chromatography at inclusion and 15 d after treatment with an adapted low-lactose formula in 20 colicky infants. RESULTS: All babies were symptomatic: 85% with excess gas, 75% with abnormal feeding pattern, and 85% with excessive crying. The hydrogen breath test at inclusion was abnormal: 35 ± 3.1 ppm. After 15 d feeding with an adapted low-lactose formula, crying and flatulence decreased in 85% of patients (P < 0.001). For infants in whom no decrease of gas was reported, crying was still reduced (P < 0.01). Moreover, the feeding pattern was improved in 50% of infants when it was initially considered as abnormal. Finally, the hydrogenbreath test decreased significantly (10 ± 2.5 ppm, P < 0.01). CONCLUSION: This study showed an association between clinical improvement and evidence of decreased levels of hydrogen when the infants were fed with a specially designed, low-lactose formula. © 2011 Baishideng. All rights reserved.
Original languageEnglish
Pages (from-to)2104-2108
JournalWorld Journal of Gastroenterology
Issue number16
Publication statusPublished - 28 Apr 2011


  • Colic
  • Hydrogen breath test
  • Infants
  • Lactose


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