Dietary and pharmacological control of calcium and phosphate metabolism in dialysis patients

J. Bover, E. Andrés, M. J. Lloret, A. Aguilar, J. Ballarín

    Research output: Contribution to journalReview articleResearchpeer-review

    10 Citations (Scopus)

    Abstract

    Chronic kidney disease-mineral and bone disorder is a new term defining a complex syndrome which underlines the need of a systemic approach to disturbances of calcium and phosphate metabolism in patients with renal failure. In recent years, the availability of new phosphorus binders and the appearance of new selective vitamin D receptor activators and calcimimetics have increased our current armamentarium and have changed previous paradigms. All these drugs can be used in combination, acting in distinct yet complementary pathways, with a resultant improvement in their individual clinical profile and reduction in secondary effects, while enhancing the achievement of clinical guideline targets. On the other hand, we should be aware that treatment costs are increasing and most of our knowledge is opinion-based. In this article, we shall consider rational recommendations on the control of calcium, phosphorus and parathyroid hormone while awaiting new evidence. We shall also briefly review some important related issues such as vascular calcification, adynamic bone disease, osteoporosis and the need of parathyroidectomy. Future guidelines may modify current recommendations, but we believe that the lack of an absolute evidence is not equivalent to the lack of awareness of the important problem which chronic kidney disease-mineral and bone disorder represents. Copyright © 2009 S. Karger AG, Basel.
    Original languageEnglish
    Pages (from-to)369-386
    JournalBlood Purification
    Volume27
    Issue number4
    DOIs
    Publication statusPublished - 1 May 2009

    Keywords

    • Adynamic bone disease
    • Calcimimetics
    • Chronic kidney disease
    • Lanthanum
    • Paricalcitol
    • Phosphorus binders
    • Secondary hyperparathyroidism
    • Sevelamer
    • Vascular calcification
    • Vitamin D

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