Diagnostic yield of prothrombotic state studies in cryptogenic stroke

R. Belvís, A. Santamaría, J. Martí-Fàbregas, D. Cocho, M. Borrell, J. Fontcuberta, J. L. Martí-Vilalta

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12 Citations (Scopus)


Objectives - Around 30% of ischemic strokes are considered cryptogenic. We analyzed the diagnostic yield of prothrombotic state (PS) studies in patients with an initial cryptogenic stroke (CS). Material and methods - We prospectively included consecutive CS patients according to the TOAST criteria. PS included plasmatic determinations of antiphospholipid (APL) antibodies and lupus anticoagulant (LA), S (SPd) and C (CPd) protein deficiencies, and genetic analysis of the prothrombin gene mutation (PTG20210A) and the factor V Leiden mutation (FVG1691A). We recorded age, sex and vascular risk factors. Results - From a total of 89 patients (mean age 56.9 ± 14.3 years, 53% men), we identified 16 PS in 15 patients (16.85%): APL-6, LA-2, SPd-2, CPd-1, PTG20210A-3 and FVG1691A-2. One patient presented an association (APL and PTG20210A). Conclusions - One of every six patients with initial CS present a PS. Age or sex and conventional cardiovascular risk factors were not related to PS study findings, supporting the relevance of such studies in all patients with an initial CS. © 2006 The Authors.
Original languageEnglish
Pages (from-to)250-253
JournalActa Neurologica Scandinavica
Issue number4
Publication statusPublished - 1 Oct 2006


  • Antiphospholipid
  • Cryptogenic stroke
  • Leiden
  • Prothrombin
  • Prothrombotic state


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