Diagnosis of Helicobacter pylori Infection in the Proton Pump Inhibitor Era

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20 Citations (Scopus)


© 2015 Elsevier Inc. Proton pump inhibitors (PPI) are a major cause of false-negative Helicobacter pylori test results. Detecting PPI use and stopping it 2 weeks before testing is the preferred approach to improve the reliability of H pylori diagnostic tests. Immunoblot and molecular methods may be useful for the detection of H pylori infection in difficult cases. When conventional tests are negative and eradication is strongly indicated, empirical H pylori treatment should be considered. In this article, an updated critical review of the usefulness of the various invasive and noninvasive tests in the context of extensive PPI use is provided.
Original languageEnglish
Pages (from-to)507-518
JournalGastroenterology Clinics of North America
Issue number3
Publication statusPublished - 1 Sept 2015


  • Diagnosis
  • Helicobacter pylori
  • Proton pump inhibitors
  • Treatment


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