Diagnosis and therapeutic approach of latent tuberculosis infection

José Domínguez, Irene Latorre, Miguel Santin

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)


© 2017 Elsevier España, S.L.U. and Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica Detection and treatment of latent tuberculosis infection (LTBI) is an essential measure for tuberculosis (TB) control in low-incidence countries. However, such strategy is limited by the low predictive ability of the diagnostic tests for the development of active TB among infected people and the long-term and toxic treatment regimens. The in vitro interferon-gamma release assays are more specific and sensitive than the tuberculin skin test (TST), and enable a better selection of cases requiring treatment. Nonetheless, their capacity to predict development of TB is still poor. In addition, treatment regimens for LTBI are long, and compliance rates are low. This review discusses the use of the available diagnostic tests and the new approaches to the diagnosis of LTBI, as well as its management in different clinical scenarios.
Original languageEnglish
Pages (from-to)302-311
JournalEnfermedades Infecciosas y Microbiologia Clinica
Issue number5
Publication statusPublished - 1 May 2018


  • Diagnosis
  • Interferon-gamma release assays
  • Latent tuberculosis infection
  • Treatment
  • Tuberculin skin test
  • Tuberculosis


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