Diabetes in pregnancy outcomes: A systematic review and proposed codification of definitions

Denice S. Feig, Rosa Corcoy, Dorte Moller Jensen, Alexandra Kautzky-Willer, Christopher J. Nolan, Jeremy J.N. Oats, David A. Sacks, Francisca Caimari, H. David Mcintyre

Research output: Contribution to journalReview articleResearchpeer-review

40 Citations (Scopus)

Abstract

© 2015 John Wiley & Sons, Ltd. Rising rates of diabetes in pregnancy have led to an escalation in research in this area. As in any area of clinical research, definitions of outcomes vary from study to study, making it difficult to compare research findings and draw conclusions. Our aim was to compile and create a repository of definitions, which could then be used universally. A systematic review of the literature was performed on published and ongoing randomized controlled trials in the area of diabetes in pregnancy between 01 Jan 2000 and 01 Jun 2012. Other sources included the World Health Organization and Academic Society Statements. The advice of experts was sought when appropriate definitions were lacking. Among the published randomized controlled trials on diabetes and pregnancy, 171 abstracts were retrieved, 64 full texts were reviewed and 53 were included. Among the ongoing randomized controlled trials published in ClinicalTrials.gov, 90 protocols were retrieved and 25 were finally included. The definitions from these were assembled and the final maternal definitions and foetal definitions were agreed upon by consensus. It is our hope that the definitions we have provided (i) will be widely used in the reporting of future studies in the area of diabetes in pregnancy, that they will (ii) facilitate future systematic reviews and formal meta analyses and (iii) ultimately improve outcomes for mothers and babies.
Original languageEnglish
Pages (from-to)680-690
JournalDiabetes/Metabolism Research and Reviews
Volume31
Issue number7
DOIs
Publication statusPublished - 1 Oct 2015

Keywords

  • Diabetes mellitus
  • Gestational diabetes
  • Pregnancy
  • Pregnancy in diabetic patients
  • Pregnancy outcome

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