Development of a definition for Rapid Progression (RP) of renal function in HIV-positive persons: The D:A:D study

D.A. Kamara, L. Ryom, M. Ross, O. Kirk, P. Reiss, P. Morlat, O. Moranne, C.A. Fux, A. Mocroft, C. Sabin, J.D. Lundgren, C.J. Smith, B. Powderly, N. Shortman, C. Moecklinghoff, G. Reilly, X. Franquet, C.A. Sabin, D. Kamara, C. SmithA. Phillips, J. Tverland, M. Mansfeld, J. Nielsen, D. Raben, R. Salbøl Brandt, M. Rickenbach, I. Fanti, E. Krum, M. Hillebregt, S. Geffard, A. Sundström, M. Delforge, E. Fontas, F. Torres, H. McManus, S. Wright, J. Kjær, A. Sjøl, P. Meidahl, J. Helweg-Larsen, J. Schmidt Iversen, A.M. Kesselring, R. Weber, C. Pradier, N. Friis-Møller, J. Kowalska, M. Law, A. D'Arminio Monforte, F. Dabis, M. Bruyand, M. Bower, G. Fätkenheuer, A. Donald, A. Grulich, S. Zaheri, L. Gras, J.M. Prins, T.W. Kuijpers, H.J. Scherpbier, J.T.M. Van Der Meer, F.W.M.N. Wit, M.H. Godfried, T. Van Der Poll, F.J.B. Nellen, J.M.A. Lange, S.E. Geerlings, M. Van Vugt, D. Pajkrt, J.C. Bos, M. Van Der Valk, M.L. Grijsen, W.J. Wiersinga, A. Goorhuis, J.W.R. Hovius, S. Lowe, A. Oude Lashof, D. Posthouwer, M.J.H. Pronk, H.S.M. Ammerlaan, M.E. Van Der Ende, T.E.M.S. De Vries-Sluijs, C.A.M. Schurink, J.L. Nouwen, A. Verbon, B.J.A. Rijnders, E.C.M. Van Gorp, M. Van Der Feltz, G.J.A. Driessen, A.M.C. Van Rossum, J. Branger, E.F. Schippers, C. Van Nieuwkoop, E.P. Van Elzakker, P.H.P. Groeneveld, J.W. Bouwhuis, R. Soetekouw, R.W. Ten Kate, F.P. Kroon, J.T. Van Dissel, S.M. Arend, M.G.J. De Boer, H. Jolink, H.J.M. Ter Vollaard, M.P. Bauer, J.G. Den Hollander, K. Pogany, G. Van Twillert, W. Kortmann, J.W.T. Cohen Stuart, B.M.W. Diederen, E.M.S. Leyten, L.B.S. Gelinck, G.J. Kootstra, C.E. Delsing, K. Brinkman, W.L. Blok, P.H.J. Frissen, W.E.M. Schouten, G.E.L. Van Den Berk, M.E.E. Van Kasteren, A.E. Brouwer, J. Veenstra, K.D. Lettinga, J.W. Mulder, S.M.E. Vrouenraets, F.N. Lauw, A. Van Eeden, D.W.M. Verhagen, H.G. Sprenger, R. Doedens, E.H. Scholvinck, S. Van Assen, W.F.W. Bierman, P.P. Koopmans, M. Keuter, A.J.A.M. Van Der Ven, H.J.M. Ter Hofstede, A.S.M. Dofferhoff, A. Warris, R. Van Crevel, A.I.M. Hoepelman, T. Mudrikova, M.M.E. Schneider, P.M. Ellerbroek, J.J. Oosterheert, J.E. Arends, M.W.M. Wassenberg, R.E. Barth, M.A. Van Agtmael, R.M. Perenboom, F.A.P. Claessen, M. Bomers, E.J.G. Peters, S.P.M. Geelen, T.F.W. Wolfs, L.J. Bont, C. Richter, J.P. Van Der Berg, E.H. Gisolf, M. Van Den Berge, A. Stegeman, M.G.A. Van Vonderen, D.P.F. Van Houte, S. Weijer, R. El Moussaoui, C. Winkel, F. Muskiet, O. Durand, R. Voigt, G. Chêne, S. Lawson-Ayayi, R. Thiébaut, F. Bonnal, F. Bonnet, N. Bernard, L. Caunègre, C. Cazanave, J. Ceccaldi, D. Chambon, I. Chossat, F.A. Dauchy, S. De Witte, M. Dupon, P. Duffau, H. Dutronc, S. Farbos, V. Gaborieau, M.C. Gemain, Y. Gerard, C. Greib, M. Hessamfar, D. Lacoste, P. Lataste, S. Lafarie, E. Lazaro, D. Malvy, J.P. Meraud, P. Mercié, E. Monlun, D. Neau, A. Ochoa, J.L. Pellegrin, T. Pistone, J.M. Ragnaud, M.C. Receveur, S. Tchamgoué, M.A. Vandenhende, J.F. Viallard, J.F. Moreau, I. Pellegrin, H. Fleury, M.E. Lafon, B. Masquelier, P. Trimoulet, D. Breilh, F. Haramburu, G. Miremont-Salamé, M.J. Blaizeau, M. Decoin, J. Delaune, S. Delveaux, C. D'Ivernois, C. Hanapier, O. Leleux, B. Uwamaliya-Nziyumvira, X. Sicard, G. Palmer, D. Touchard, K. Petoumenos, C. Bendall, R. Moore, S. Edwards, J. Hoy, K. Watson, N. Roth, J. Nicholson, M. Bloch, T. Franic, D. Baker, R. Vale, A. Carr, D. Cooper, J. Chuah, M. Ngieng, D. Nolan, J. Skett, G. Calvo, S. Mateu, P. Domingo, M.A. Sambeat, J. Gatell, E. Del Cacho, J. Cadafalch, M. Fuster, C. Codina, G. Sirera, A. Vaqué, N. Clumeck, C. Necsoi, A.F. Gennotte, M. Gerard, K. Kabeya, D. Konopnicki, A. Libois, C. Martin, M.C. Payen, P. Semaille, Y. Van Laethem, J. Neaton, G. Bartsch, W.M. El-Sadr, G. Thompson, D. Wentworth, R. Luskin-Hawk, E. Telzak, D.J. Abrams, D. Cohn, N. Markowitz, R. Arduino, D. Mushatt, G. Friedland, G. Perez, E. Tedaldi, E. Fisher, F. Gordin, L.R. Crane, J. Sampson, J. Baxter, J. Lundgren, A. Cozzi-Lepri, D. Grint, D. Podlekareva, L. Peters, J. Reekie, A.H. Fischer, M. Losso, C. Elias, N. Vetter, R. Zangerle, I. Karpov, A. Vassilenko, V.M. Mitsura, O. Suetnov, R. Colebunders, L. Vandekerckhove, V. Hadziosmanovic, K. Kostov, J. Begovac, L. MacHala, D. Jilich, D. Sedlacek, G. Kronborg, T. Benfield, M. Larsen, J. Gerstoft, T. Katzenstein, A.-B.E. Hansen, P. Skinhøj, C. Pedersen, L. Ostergaard, K. Zilmer, J. Smidt, M. Ristola, C. Katlama, J.-P. Viard, P.-M. Girard, J.M. Livrozet, P. Vanhems, J. Rockstroh, R. Schmidt, J. Van Lunzen, O. Degen, H.J. Stellbrink, S. Staszewski, M. Bickel, J. Kosmidis, P. Gargalianos, G. Xylomenos, J. Perdios, G. Panos, A. Filandras, E. Karabatsaki, H. Sambatakou, D. Banhegyi, F. Mulcahy, I. Yust, D. Turner, M. Burke, S. Pollack, G. Hassoun, S. Maayan, S. Vella, R. Esposito, I. Mazeu, C. Mussini, C. Arici, R. Pristera, F. Mazzotta, A. Gabbuti, V. Vullo, M. Lichtner, A. Chirianni, E. Montesarchio, M. Gargiulo, G. Antonucci, A. Testa, P. Narciso, C. Vlassi, M. Zaccarelli, A. Lazzarin, A. Castagna, N. Gianotti, M. Galli, A. Ridolfo, B. Rozentale, I. Zeltina, S. Chaplinskas, R. Hemmer, T. Staub, V. Ormaasen, A. Maeland, J. Bruun, B. Knysz, J. Gasiorowski, A. Horban, E. Bakowska, A. Grzeszczuk, R. Flisiak, A. Boron-Kaczmarska, M. Pynka, M. Parczewski, M. Beniowski, E. Mularska, H. Trocha, E. Jablonowska, E. Malolepsza, K. Wojcik, F. Antunes, M. Doroana, L. Caldeira, K. Mansinho, F. Maltez, D. Duiculescu, A. Rakhmanova, N. Zakharova, S. Buzunova, D. Jevtovic, M. Mokráš, D. Staneková, J. Tomazic, J. González-Lahoz, V. Soriano, P. Labarga, J. Medrano, S. Moreno, J.M. Rodriguez, B. Clotet, A. Jou, R. Paredes, C. Tural, J. Puig, I. Bravo, J.M. Gatell, J.M. Miró, M. Gutierrez, G. Mateo, A. Karlsson, L. Flamholc, B. Ledergerber, P. Francioli, M. Cavassini, B. Hirschel, E. Boffi, H. Furrer, M. Battegay, L. Elzi, E. Kravchenko, N. Chentsova, V. Frolov, G. Kutsyna, S. Servitskiy, M. Krasnov, S. Barton, A.M. Johnson, D. Mercey, M.A. Johnson, M. Murphy, J. Weber, G. Scullard, M. Fisher, C. Leen, L. Morfeldt, G. Thulin, B. Åkerlund, K. Koppel, C. Håkangård, M. Moroni, G. Angarano, A. Antinori, O. Armignacco, F. Castelli, R. Cauda, G. Di Perri, R. Iardino, G. Ippolito, C.F. Perno, F. Von Schloesser, P. Viale, F. Ceccherini-Silberstein, E. Girardi, S. Lo Caputo, M. Puoti, A. Ammassari, A. Ttinoriz, C. Balotta, P. Bonfanti, S. Bonora, M. Borderi, M.R. Capobianchi, A. Cingolani, P. Cinque, A. De Luca, A. Di Biagio, A. Gori, G. Guaraldi, G. Lapadula, G. Madeddu, F. Maggiolo, G. Marchetti, S. Marcotullio, L. Monno, S. Rusconi, A. Cozzi-Lepric, P. Cicconi, T. Formenti, L. Galli, P. Lorenzini, A. Giacometti, A. Costantini, C. Santoro, C. Suardi, E. Vanino, G. Verucchi, R. Gere, E. Quiros Roldan, C. Minardi, T. Quirino, C. Abeli, P.E. Manconi, P. Piano, J. Vecchiet, K. Falasca, L. Sighinolfi, D. Segala, G. Cassola, G. Viscoli, A. Alessandrini, R. Piscopo, G. Mazzarello, C. Mastroianni, V. Belvisi, I. Caramma, R. KGF, G. Rizzardini, R. Piolini, S. Salpietro, L. Carenzi, M.C. Moioli, C. Puzzolante, N. Abrescia, M.G. Guida, M. Onofrio, F. Baldelli, D. Francisci, G. Parruti, T. Ursini, G. Magnani, M.A. Ursitti, M. Andreoni, A. D'Avino, L. Gallo, E. Nicastri, R. Acinapura, M. Capozzi, R. Libertone, G. Tebano, A. Cattelan, M.S. Mura, P. Caramello, G.C. Orofino, M. Sciandra, G. Pellizzer, V. Manfrin, C. Caissotti, P. Dellamonica, E. Bernard, E. Cua, F. De Salvador-Guillouet, J. Durant, S. Ferrando, V. Mondain-Miton, A. Naqvi, I. Perbost, B. Prouvost-Keller, S. Pillet, P. Pugliese, V. Rahelinirina, P.M. Roger, K. Dollet, V. Aubert, J. Barth, E. Bernasconi, J. Böni, H.C. Bucher, C. Burton-Jeangros, A. Calmy, M. Egger, J. Fehr, J. Fellay, M. Gorgievski, H. Günthard, D. Haerry, B. Hasse, H.H. Hirsch, I. Hösli, C. Kahlert, L. Kaiser, O. Keiser, T. Klimkait, H. Kovari, G. Martinetti, B. Martinez De Tejada, K. Metzner, N. Müller, D. Nadal, G. Pantaleo, A. Rauch, A. Regenass, C. Rudin, P. Schmid, D. Schultze, F. Schöni-Affolter, J. Schüpbach, R. Speck, P. Taffé, P. Tarr, A. Telenti, A. Trkola, P. Vernazza, S. Yerly, D:A:D study Group

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Abstract

Background: No consensus exists on how to define abnormally rapid deterioration in renal function (Rapid Progression, RP). We developed an operational definition of RP in HIV-positive persons with baseline estimated glomerular filtration rate (eGFR) >90 ml/min/1.73 m2 (using Cockcroft Gault) in the Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) study from 2004 to 2011. Methods: Two definitions were evaluated; RP definition A: An average eGFR decline (slope) =5 ml/min/1.73 m2/year over four years of follow-up with =3 eGFR measurements/year, last eGFR
Original languageEnglish
JournalBMC Nephrology
Volume15
Issue number1
DOIs
Publication statusPublished - Jan 2014

Keywords

  • Chronic kidney disease
  • Estimated glomerular filtration rate
  • HIV
  • Kidney disease
  • Rapid progression
  • adult
  • article
  • chronic kidney disease
  • disease association
  • disease course
  • female
  • follow up
  • glomerulus filtration rate
  • human
  • Human immunodeficiency virus infected patient
  • Human immunodeficiency virus infection
  • kidney function
  • major clinical study
  • male
  • observational study
  • prediction
  • rapid progression
  • risk factor
  • sensitivity and specificity
  • aged
  • algorithm
  • clinical trial
  • complication
  • computer assisted diagnosis
  • HIV Infections
  • international cooperation
  • middle aged
  • multicenter study
  • procedures
  • Renal Insufficiency, Chronic
  • reproducibility
  • severity of illness index
  • very elderly
  • Adult
  • Aged
  • Aged, 80 and over
  • Algorithms
  • Diagnosis, Computer-Assisted
  • Disease Progression
  • Female
  • Glomerular Filtration Rate
  • Humans
  • Internationality
  • Male
  • Middle Aged
  • Reproducibility of Results
  • Sensitivity and Specificity
  • Severity of Illness Index

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